{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:24:54Z","timestamp":1790375094082,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,9]]},"abstract":"<jats:p>Acne is the eighth most frequent disease worldwide. Inflammatory response runs through all stages of acne. It is complicated and is involved in innate and adaptive immunity. This study aimed to explore the candidate genes and their relative signaling pathways in inflammatory acne using data mining analysis. Microarray data GSE6475 and GSE53795, including 18 acne lesion tissues and 18 matched normal skin tissues, were obtained. Differentially expressed genes (DEGs) were filtered and subjected to functional and pathway enrichment analyses. Protein\u2013protein interaction (PPI) network and module analyses were also performed based on the DEGs. In this work, 154 common DEGs, including 145 upregulated and 9 downregulated, were obtained from two microarray profiles. Gene Ontology and pathway enrichment of DEGs were clustered using significant enrichment analysis. A PPI network containing 110 nodes\/DEGs was constructed, and 31 hub genes were obtained. Four modules in the PPI network, which mainly participated in chemokine signaling pathway, cytokine\u2013cytokine receptor interaction, and Fc gamma R-mediated phagocytosis, were extracted. In conclusion, aberrant DEGs and pathways involved in acne pathogenesis were identified using bioinformatic analysis. The DEGs included FPR2, ITGB2, CXCL8, C3AR1, CXCL1, FCER1G, LILRB2, PTPRC, SAA1, CCR2, ICAM1, and FPR1, and the pathways included chemokine signaling pathway, cytokine\u2013cytokine receptor interaction, and Fc gamma R-mediated phagocytosis. This study could serve as a basis for further understanding the pathogenesis and potential therapeutic targets of inflammatory acne.<\/jats:p>","DOI":"10.1155\/2019\/3739086","type":"journal-article","created":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T19:31:01Z","timestamp":1560108661000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics"],"prefix":"10.1155","volume":"2019","author":[{"given":"Biao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Guangzhou Women and Children Medical Center, No. 9 Jinsui Road, Guangzhou, Guangdong 510623, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-8419","authenticated-orcid":true,"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, Henan 450052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8315-1661","authenticated-orcid":true,"given":"Yanhua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, 1333 Xinhu Road, Shenzhen, Guangdong 518101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13462"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137794"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14385"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14374"},{"key":"5","volume":"142, article w13590","year":"2012","journal-title":"Swiss Medical Weekly"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700213"},{"key":"7","volume":"9, article e105238","year":"2014","journal-title":"PLoS ONE"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.111"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.438"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.309"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12298"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.334"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.09.012"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.05.015"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00716.x"},{"issue":"2","key":"16","first-page":"86","volume":"20","year":"2017","journal-title":"Archives of Iranian Medicine"},{"key":"17","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/jcp.27262","volume":"234","year":"2019","journal-title":"Journal of Cellular Physiology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13775"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-017-2369-3"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.04.030"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12320"},{"key":"22","volume":"8, article 1595","year":"2017","journal-title":"Nature Communications"},{"key":"23","volume":"9, article ra86","year":"2016","journal-title":"Science Signaling"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.05.037"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2017.05.005"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/3739086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/3739086.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/3739086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T19:31:03Z","timestamp":1560108663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/3739086\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,9]]},"references-count":25,"alternative-id":["3739086","3739086"],"URL":"https:\/\/doi.org\/10.1155\/2019\/3739086","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,9]]}}}