{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:36:01Z","timestamp":1747190161468,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2019,8,19]]},"abstract":"<jats:p>Esthesioneuroblastoma (ENB) is a rare malignant tumor that commonly develops in the upper nasal cavity. Standard treatment is not established, especially in locally advanced disease which portends the worse prognosis. Hereby, we report a case of a 27-year-old, 23-week pregnant woman, with a 2-month history of progressively growing right cervical lymphadenopathy, nasal obstruction, anosmia, frequent episodes of epistaxis, and right frontal headache. Imagiological evaluation revealed a lesion with 7\u00d75,2\u00d73,2\u2009cm in the nasal fossae with extension to the ethmoidal complex and right olfactive fend and invasion of the endocranial compartment associated with lymphadenopathy. The biopsy revealed a high-grade EBN. Neoadjuvant chemotherapy with cisplatin and etoposide was administrated during pregnancy and continued after delivery up to 6 cycles of treatment with partial response. Radiotherapy followed, with complete response. This case report is intended to highlight that a high grade of suspicion should be kept in the presence of nonspecific symptoms of nasal obstruction, anosmia, facial pain, and\/or headache and focus that chemotherapy is an important component of a combined-treatment modality for locally advanced ENB that can be used during pregnancy in a lifesaving situation.<\/jats:p>","DOI":"10.1155\/2019\/3789317","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T19:31:35Z","timestamp":1566243095000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Management of Locally Advanced Esthesioneuroblastoma in a Pregnant Woman"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-7605","authenticated-orcid":true,"given":"In\u00eas Maria","family":"Guerreiro","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Vieira","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Soares","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil (IPO-PORTO), Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centro Hospitalar do Porto, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"J\u00e1come","sequence":"additional","affiliation":[{"name":"Pathology Department, Instituto Portugu\u00eas de Oncologia do Porto Francisco 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