{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:52:11Z","timestamp":1790283131172,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bpi France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,23]]},"abstract":"<jats:p>Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though interaction with urine-contaminated environment. Many wildlife species living close to cattle, especially commensal rodents may play a role in the transmission of leptospires. Because little is known on the epidemiology of nonmaintenance<jats:italic> Leptospira<\/jats:italic> serovars, appropriate management is still limited. On a French farm where human and cattle leptospirosis were detected, the transmission cycle was explored to propose appropriate mitigation measures. For that, commensal rodents present on the farm were trapped and their leptospires carriage was studied by molecular methods. Trapped mice were shown to carry two pathogenic<jats:italic> Leptospira<\/jats:italic> species (<jats:italic>L. interrogans<\/jats:italic> and<jats:italic> L. kirschneri<\/jats:italic>). Since these 2 serogroups were simultaneously detected in the trapped mice and in the cows of this farm, we suspected an initial<jats:italic> Leptospira<\/jats:italic> transmission from mice to cows requiring an effective management of mice on this farm. Because resistance to anticoagulant rodenticides due to<jats:italic> Vkorc1<\/jats:italic> mutations has been largely described in rodents and first-generation anticoagulant rodenticides seemed to be inefficient in controlling mice on this farm, susceptibility of these mice to anticoagulants has been characterized by<jats:italic> Vkorc1<\/jats:italic> sequencing. 50% of the trapped mice carried mutations in the<jats:italic> Vkorc1<\/jats:italic> gene leading to severe resistance to first-generation anticoagulants. The management of such mice that are a real sanitary threat can be achieved only by using the most toxic second-generation anticoagulants or nonanticoagulant solutions.<\/jats:p>","DOI":"10.1155\/2019\/3794876","type":"journal-article","created":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T19:31:27Z","timestamp":1561318287000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management"],"prefix":"10.1155","volume":"2019","author":[{"given":"Aur\u00e9lie","family":"Marquez","sequence":"first","affiliation":[{"name":"USC 1233 RS2GP, VetAgro Sup, INRA, University of Lyon, 69280 Marcy-l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Ulivieri","sequence":"additional","affiliation":[{"name":"Laboratoire des Leptospires, VetAgro Sup, 69280 Marcy-l\u2019Etoile, 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