{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:05Z","timestamp":1790254265316,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T00:00:00Z","timestamp":1558224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cancer Research Malaysia","award":["PS230\/2009C"],"award-info":[{"award-number":["PS230\/2009C"]}]},{"name":"Cancer Research Malaysia","award":["06-061"],"award-info":[{"award-number":["06-061"]}]},{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["PS230\/2009C"],"award-info":[{"award-number":["PS230\/2009C"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["06-061"],"award-info":[{"award-number":["06-061"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Malaysia","award":["PS230\/2009C"],"award-info":[{"award-number":["PS230\/2009C"]}]},{"name":"Ministry of Health, Malaysia","award":["06-061"],"award-info":[{"award-number":["06-061"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,5,19]]},"abstract":"<jats:p>Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer prevalent in Southern China and Southeast Asia. The current knowledge on the molecular pathogenesis of NPC is still inadequate to improve disease management. Using gene expression microarrays, we have identified the<jats:italic>four-jointed box 1<\/jats:italic>(<jats:italic>FJX1<\/jats:italic>) gene to be upregulated in primary NPC tissues relative to nonmalignant tissues. An orthologue of human<jats:italic>FJX1<\/jats:italic>, the<jats:italic>four-jointed (fj)<\/jats:italic>gene in Drosophila and<jats:italic>Fjx1<\/jats:italic>in mouse, has reported to be associated with cancer progression pathways. However, the exact function of FJX1 in human is not well characterized. The overexpression of FJX1 mRNA was validated in primary NPC tissue samples, and the level of FJX1 protein was significantly higher in a subset of NPC tissues (42%) compared to the normal epithelium, where no expression of FJX1 was observed (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). FJX1 is also found to be overexpressed in microarray datasets and TCGA datasets of other cancers including head and neck cancer, colorectal, and ovarian cancer. Both siRNA knockdown and overexpression experiments in NPC cell lines showed that FJX1 promotes cell proliferation, anchorage-dependent growth, and cellular invasion. Cyclin D1 and E1 mRNA levels were increased following FJX1 expression indicating that FJX1 enhances proliferation by regulating key proteins governing the cell cycle. Our data suggest that the overexpression of FJX1 contributes to a more aggressive phenotype of NPC cells and further investigations into FJX1 as a potential therapeutic target for NPC are warranted. The evaluation of FJX1 as an immunotherapy target for NPC and other cancers is currently ongoing.<\/jats:p>","DOI":"10.1155\/2019\/3857853","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T23:30:47Z","timestamp":1558308647000},"page":"1-10","source":"Crossref","is-referenced-by-count":15,"title":["An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-9301","authenticated-orcid":true,"given":"San Jiun","family":"Chai","sequence":"first","affiliation":[{"name":"Cancer Research Malaysia, No. 1, Jalan SS12\/1A, Subang Jaya, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Mamduh","family":"Ahmad Zabidi","sequence":"additional","affiliation":[{"name":"Cancer Research Malaysia, No. 1, Jalan SS12\/1A, Subang Jaya, Selangor, Malaysia"},{"name":"Institute of Biological Sciences, Faculty of Science, 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