{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:40:06Z","timestamp":1787820006037,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Islamia University of Bahawalpur"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,12,6]]},"abstract":"<jats:p>We aimed to study the effects of <jats:italic>Citrus aurantium<\/jats:italic> (<jats:italic>C. aurantium<\/jats:italic>) on renal functions in cisplatin-induced nephrotoxicity in rats. The study involved male Wistar rats weighing 250\u2013300\u2009g that were fed and kept under standard conditions. Rats were randomly divided into control, cisplatin administered, <jats:italic>C. aurantium<\/jats:italic> 200\u2009mg\/kg, and <jats:italic>C. aurantium<\/jats:italic> 400\u2009mg\/kg groups. Cisplatin was administered at 5\u2009mg\/kg i.p. once at the start of study to induce nephrotoxicity. Blood and urine samples were obtained at alternative days for analysis. The body weight and urine output were monitored at regular intervals. Plasma and urinary sodium, potassium, and creatinine levels were measured at the end of study duration. Absolute excretion of sodium and potassium; sodium to potassium ratio; kidney weights; fractional excretion of sodium and potassium; and absolute creatinine clearance were determined to analyze the effects of <jats:italic>C. aurantium<\/jats:italic>. Histopathological changes of kidney tissues were studied to determine relevant effects. The results indicate that cisplatin lowered the total body weights while raising the urinary output and kidney weights, reversed by <jats:italic>C. aurantium<\/jats:italic> both dose and time dependently. Similarly, <jats:italic>C.<\/jats:italic> aurantium markedly normalized plasma, urinary sodium, potassium, and creatinine levels. Cisplatin-induced absolute sodium clearance, absolute potassium clearance, absolute creatinine clearance, sodium to potassium ratio, and fractional excretion of sodium and potassium were significantly reversed by <jats:italic>C.<\/jats:italic> aurantium. Histopathological analysis showed notable improvement in <jats:italic>C.<\/jats:italic> aurantium administered groups as compared to cisplatin-induced group. Study suggests that <jats:italic>C. aurantium<\/jats:italic> possesses excellent nephroprotective effects against cisplatin-induced toxicity.<\/jats:p>","DOI":"10.1155\/2019\/3960908","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T18:32:15Z","timestamp":1575657135000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["<i>Citrus aurantium<\/i> Ameliorates Cisplatin-Induced Nephrotoxicity"],"prefix":"10.1155","volume":"2019","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Zhenzhou Central Hospital, Affiliated to Zhengzhou University, Zhengzhou City, Henan Province 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-1736","authenticated-orcid":true,"given":"Waseem","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 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