{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:47:50Z","timestamp":1756385270192,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2019,7,25]]},"abstract":"<jats:p>Local anesthesia with mepivacaine is used for vaginal deliveries and for minor surgeries of the vagina and perineum as repair of an episiotomy or perineal laceration. Neonatal intoxication caused by local anesthesia with mepivacaine for maternal episiotomy has been rarely reported. We present a case of a term female infant with unexplained cardiorespiratory distress and several neurologic findings, including seizures, one hour after birth. Electrocardiogram showed a second-degree atrioventricular block and a left-bundle branch block. Blood measures in the patient revealed a high mepivacaine level following local anesthesia for maternal episiotomy. Because of the increasing practice of local anesthesia, high awareness for neonatal intoxication and further research in safe elimination therapy in neonates is needed.<\/jats:p>","DOI":"10.1155\/2019\/4013564","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T19:31:23Z","timestamp":1564083083000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Severe Cardiorespiratory and Neurologic Symptoms in a Neonate due to Mepivacaine Intoxication"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-4119","authenticated-orcid":true,"given":"Maurike","family":"de Groot-van der Mooren","sequence":"first","affiliation":[{"name":"Department of Neonatology, Emma Children\u2019s Hospital and VU University Medical Center, Boelelaan 1117, Amsterdam 1081 HV, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Quint","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emma Children\u2019s Hospital and VU University Medical Center, Boelelaan 1117, Amsterdam 1081 HV, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingmar","family":"Knobbe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Emma Children\u2019s Hospital and VU University Medical Center, Boelelaan 1117, Amsterdam 1081 HV, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Cronie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Onze Lieve Vrouwe Gasthuis, Jan Tooropstraat 164, Amsterdam 1061 AE, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"van Weissenbruch","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emma Children\u2019s Hospital and VU University Medical Center, Boelelaan 1117, Amsterdam 1081 HV, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2018.06.010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7481.34"},{"issue":"4","key":"3","first-page":"191","volume":"187","year":"1983","journal-title":"Z Geburtshilfe Perinatol"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(79)80539-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/bf02072637"},{"issue":"5","key":"6","first-page":"643","volume":"64","year":"1979","journal-title":"Pediatrics"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3233\/npm-1791"},{"issue":"4","key":"8","first-page":"341","volume":"2","year":"1982","journal-title":"Pediatr Pharmacol (New York)"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03670.x"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2019\/4013564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2019\/4013564.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2019\/4013564.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T19:31:24Z","timestamp":1564083084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripe\/2019\/4013564\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":9,"alternative-id":["4013564","4013564"],"URL":"https:\/\/doi.org\/10.1155\/2019\/4013564","relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}