{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:36:22Z","timestamp":1747190182796,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Vascular Medicine"],"published-print":{"date-parts":[[2019,12,15]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions. <jats:italic>Objective<\/jats:italic>. To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats. <jats:italic>Methods<\/jats:italic>. Male Wistar rats were divided into 3 groups: (i) Sham (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:mrow><\/mml:math>), animals exposed to carotid arteries dissection without clamping; (ii) Control (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:mrow><\/mml:math>), animals that received an intraperitoneal injection of 0.9% saline solution (0.1\u2009mL\/kg) and underwent carotid arteries dissection with temporary clamping; (iii) Vitamin C (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:mrow><\/mml:math>), animals that received an intraperitoneal injection of vitamin C (750\u2009mg\/kg) and underwent carotid arteries dissection with temporary clamping. Behavioral assessment was then performed in all groups, which included the open field, Morris water maze and rotarod tests. Levels of malondialdehyde (MDA) in the hippocampus and striatum were measured using a fluorometric assay. <jats:italic>Results<\/jats:italic>. Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>), but it was significantly different from controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Vitamin C was also found to reduce MDA levels in both hippocampus and striatum when compared to placebo (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.<\/jats:p>","DOI":"10.1155\/2019\/4090549","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T18:30:17Z","timestamp":1576434617000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-8049","authenticated-orcid":true,"given":"Kelston Paulo Felice","family":"de Sales","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Ara\u00fajo 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