{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:31:22Z","timestamp":1790793082760,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T00:00:00Z","timestamp":1567900800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Biotree Biotech Co. Ltd","award":["81673880"],"award-info":[{"award-number":["81673880"]}]},{"name":"Shanghai Biotree Biotech Co. 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The metabolites were analyzed to discover the substance that serves as the underlying basis of the damp phlegm pattern. This analysis is based on the Traditional Chinese Medicine (TCM) theory of \u201cdifferent diseases have the same pattern.\u201d The metabolic spectrum was obtained through the Gas Chromatography Mass Spectrometry coupling techniques and analyzed by searching the METLIN and HMDB databases. Some metabolites related to amino acids and glucose metabolism were identified in the tongue-coating samples from damp phlegm pattern patients by comparing them to nondamp phlegm pattern patients and healthy subjects. In addition, there were five common metabolites in the tongue-coating samples from CHD damp phlegm pattern patients compared to CRF damp phlegm pattern patients, which allowed us to understand the theory of \u201cdifferent diseases have the same pattern.\u201d In the future, the metabolites identified in this study may be used as noninvasive and convenient biomarkers to distinguish the damp phlegm pattern of CHD and CRF patients.<\/jats:p>","DOI":"10.1155\/2019\/4106293","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:30:59Z","timestamp":1567971059000},"page":"1-14","source":"Crossref","is-referenced-by-count":10,"title":["Metabolomic Markers in Tongue-Coating Samples from Damp Phlegm Pattern Patients of Coronary Heart Disease and Chronic Renal Failure"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-2369","authenticated-orcid":true,"given":"Yiming","family":"Hao","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Health Identification and Assessment\/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Haohai Biological Technology Co., Ltd., Shanghai 200052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yan","sequence":"additional","affiliation":[{"name":"Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu Province 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekai","family":"Rohlsen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-8027","authenticated-orcid":true,"given":"Peng","family":"Qian","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Health Identification and Assessment\/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-8090","authenticated-orcid":true,"given":"Feng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-7495","authenticated-orcid":true,"given":"Yiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Health Identification and Assessment\/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"3","first-page":"958","volume":"52","year":"2011","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"4","first-page":"374","volume":"47","year":"2006","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"6","first-page":"1920","volume":"28","year":"2010","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"7","first-page":"1053","volume":"28","year":"2013","journal-title":"China Journal of TCM and 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