{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:36:30Z","timestamp":1775000190182,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T00:00:00Z","timestamp":1555804800000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    . This paper revisits Papillon\u2010Lef\u00e8vre syndrome (PLS), addresses its diagnostic update and dental management, and reports a case of a 5\u2010year\u2010old Lebanese patient with consanguineously married parents.\n                    <jats:italic>Background<\/jats:italic>\n                    . PLS, also known as \u201ckeratoris palmoplantaris with periodontopathia\u201d and \u201chyperkeratosis palmoplantaris with periodontosis,\u201d is an extremely rare autosomal\u2010recessive trait that combines a diffuse palmoplantar hyperkeratosis and a severe generalized, progressive prepubertal form of a precocious form of juvenile, aggressive periodontitis.\n                    <jats:italic>Case Description<\/jats:italic>\n                    . We are reporting a 5\u2010year\u2010old boy that sustained a spontaneous loss of all his primary teeth. At consultation, he was under treatment for hyperkeratosis of his palms and soles. Detailed family history of the child revealed that the patient\u2019s parents, grandparents, and relatives were consanguineously married and two of his cousins displayed similar clinical signs (palmoplantar hyperkeratosis and premature loss of deciduous and most of the permanent teeth).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . PLS is an extremely rare disorder that usually becomes apparent from approximately 1\u20105 years of age. Genetic counseling should always be suggested to parents of affected children, informing them of chances of their offspring having the inherited disease.\n                  <\/jats:p>","DOI":"10.1155\/2019\/4210347","type":"journal-article","created":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T19:30:58Z","timestamp":1555875058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Papillon\u2010Lef\u00e8vre Syndrome: Diagnosis, Dental Management, and a Case Report"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jean-Claude","family":"Abou Chedid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Salameh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbass","family":"El-Outa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-3987","authenticated-orcid":false,"given":"Ziad E. 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