{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:00:39Z","timestamp":1784761239539,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Orthopedics"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:p><jats:italic>Case Report<\/jats:italic>.<jats:italic>Aspergillus<\/jats:italic>osteomyelitis is a destructive and progressive infection that has been described both in immunosuppressed and in immunocompetent hosts. We describe a case of lumbar vertebral osteomyelitis in a 61-year-old immunocompetent patient due to<jats:italic>Aspergillus nidulans<\/jats:italic>that was successfully treated with a combination of extensive surgical debridement, spinal stabilization, and a prolonged course of antifungal therapy. Imaging demonstrated findings consistent with L3 discitis. The biopsy grew<jats:italic>Aspergillus<\/jats:italic>fungus and was treated with vorconizole. Imaging showed progressive destructive osteomyelitis at L3-L4. Patient underwent anterior L3 and L4 partial corpectomies, anterior interbody fusion L3-L5, and posterior T11-S2 pedicle screw and rod fixation. Antifungal treatment resulted in resolution of infection.<jats:italic>Aspergillus<\/jats:italic>markers remain negative. One year following definitive treatment, the patient\u2019s back pain remains resolved.<jats:italic>Conclusion<\/jats:italic>. Definitive surgical resection of the infection, spinal stabilization, and aggressive antifungal therapy were required to eradicate the infection.<\/jats:p>","DOI":"10.1155\/2019\/4268468","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T23:33:04Z","timestamp":1562110384000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["Progressive Back Pain due to<i>Aspergillus nidulans<\/i>Vertebral Osteomyelitis in an Immunocompetent Patient: Surgical and Antifungal Management"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-0295","authenticated-orcid":true,"given":"Mark K.","family":"Lyons","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Neal","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-0349","authenticated-orcid":true,"given":"Holenarasipur R.","family":"Vikram","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.12.008"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1086\/514774"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12389"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq039"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(85)80008-0"},{"key":"6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1542\/peds.70.3.455","volume":"70","year":"1982","journal-title":"Pediatrics"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199012000-00027"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.93693"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ482"},{"key":"10","first-page":"117","volume":"23","year":"2019","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199173030-00018"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2012.12.003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s002640000205"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802545600"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.3.1376-1378.2004"}],"container-title":["Case Reports in Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crior\/2019\/4268468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crior\/2019\/4268468.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crior\/2019\/4268468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T20:06:07Z","timestamp":1663877167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crior\/2019\/4268468\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":15,"alternative-id":["4268468","4268468"],"URL":"https:\/\/doi.org\/10.1155\/2019\/4268468","relation":{},"ISSN":["2090-6749","2090-6757"],"issn-type":[{"value":"2090-6749","type":"print"},{"value":"2090-6757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]}}}