{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:51:44Z","timestamp":1762005104059,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2019,4,17]]},"abstract":"<jats:p><jats:italic>Cladophialophora bantiana<\/jats:italic>, a melanized neurotropic fungus, is the most commonly reported agent of cerebral phaeohyphomycosis. We present a case of cerebral phaeohyphomycosis due to<jats:italic>C. bantiana<\/jats:italic>with a concomitant<jats:italic>Nocardia<\/jats:italic>infection in the lung. The patient was a 64-year-old male who presented with one-week history of productive cough, confusion, and staggering gait. Brain MRI showed multiple enhancing masses, and chest CT demonstrated multifocal consolidation. To confirm diagnosis, brain biopsy was performed that showed<jats:italic>Cladophialophora bantiana<\/jats:italic>. Bronchoscopic lung biopsy confirmed infection with<jats:italic>Nocardia araoensis<\/jats:italic>. The patient was treated with trimethoprim-sulfamethoxazole, meropenem, voriconazole, and liposomal amphotericin in addition to partial resection of the brain mass. After several weeks in the hospital and deteriorating status with poor prognosis, medical care was withdrawn.<jats:italic>Cladophialophora bantiana<\/jats:italic>infection is rare and requires multidisciplinary approach for accurate diagnostic confirmation. Aggressive and long-term treatment with voriconazole along with early neurosurgical intervention may offer an improved chance of survival in these patients.<\/jats:p>","DOI":"10.1155\/2019\/4352040","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:01:56Z","timestamp":1555545716000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["<i>Cladophialophora bantiana<\/i>Cerebral Phaeohyphomycosis Complicated by Pulmonary Nocardiosis: A Tale of Two Infections"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7618-4289","authenticated-orcid":true,"given":"Muhammad Farhan","family":"Khaliq","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-6534","authenticated-orcid":true,"given":"Rayan E.","family":"Ihle","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Critical Care, West Virginia University, Charleston Division, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8236-5545","authenticated-orcid":true,"given":"Christopher P.","family":"Schirtzinger","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"2011","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780801914906"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1086\/380635"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/QCO.0000000000000334","volume":"30","year":"2017","journal-title":"Current Opinion in Infectious Disease"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1598248"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.5455\/2320-6012.ijrms20140208"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.5799\/jmid.123134"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv091"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00956.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00653-10"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/smj.0b013e318164e289"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/12830378"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"14","first-page":"1301","volume":"5","year":"2011","journal-title":"Journal of Clinical Diagnosis and Research"},{"first-page":"503","volume-title":"Agents of phaeohyphomycosis","year":"1998","key":"15"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-018-0314-0"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_448_16"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(18)30030-9"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1301635"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.01.009"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2019\/4352040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2019\/4352040.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2019\/4352040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T18:26:34Z","timestamp":1607279194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criid\/2019\/4352040\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,17]]},"references-count":20,"alternative-id":["4352040","4352040"],"URL":"https:\/\/doi.org\/10.1155\/2019\/4352040","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"type":"print","value":"2090-6625"},{"type":"electronic","value":"2090-6633"}],"subject":[],"published":{"date-parts":[[2019,4,17]]}}}