{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:22:35Z","timestamp":1782307355925,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Preventive Medicine"],"published-print":{"date-parts":[[2019,8,5]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Antibiotic resistance is a global challenge in the public health sector and also a major challenge in Ethiopia. It is truly difficult to report bacterial antibiotic resistance pattern in Ethiopia due to the absence of a review which is done comprehensively. The aim of this systematic review was to provide an overview of the works of literature on the antibiotic resistance pattern of the specific bacterial isolates that can be obtained from different clinical samples in the context of Ethiopia.<jats:italic>Materials and Methods<\/jats:italic>. A web-based search using PubMed, Google Scholar, Hinari, Sci Hub, Scopus and the Directory of Open Access Journals was conducted from April to May 2018 for published studies without restriction in the year of publication. Works of literature potentially relevant to the study were identified by Boolean search technique using various keywords: Bacterial infection, antimicrobial resistance, antibiotic resistance, drug resistance, drug susceptibility, anti-bacterial resistance, Ethiopia. Study that perform susceptibility test from animal or healthy source using &lt;10 isolates and methods other than prospective cross-sectional were excluded.<jats:italic>Results<\/jats:italic>. The database search delivered a total of 3459 studies. After amendment for duplicates and inclusion and exclusion criteria, 39 articles were found suitable for the systematic review. All studies were prospective cross-sectional in nature. The review encompasses 12 gram-positive and 15 gram-negative bacteria with their resistance pattern for around 12 antibiotics. It covers most of the regions which are found in Ethiopia. The resistance pattern of the isolates ranged from 0% up to 100%. The overall resistance of<jats:italic>M. tuberculosis<\/jats:italic>for antituberculosis drugs ranges from 0% up to 32.6%. The percentage of resistance increases among previously treated tuberculosis cases.<jats:italic>Neisseria gonorrhea,<\/jats:italic>S. typhimurium, S. Virchow, Group A Streptococci (GAS), and Group B Streptococci (GBS) were highly susceptible for most of the tested antibiotics. Methicillin-Resistant<jats:italic>Staphylococcus aureus<\/jats:italic>was highly resistant to most of the antibiotics with a slightly increased susceptibility to gentamycin.<jats:italic>Conclusions<\/jats:italic>. Total bacterial isolates obtained from a different source of sample and geographic areas were 28, including<jats:italic>M. tuberculosis<\/jats:italic>. Majority of the bacterial isolates were resistant to commonly used antibiotics. A continuous monitoring and studies on the multidrug-resistant bacterial isolates are important measures.<\/jats:p>","DOI":"10.1155\/2019\/4380309","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T23:31:03Z","timestamp":1565047863000},"page":"1-10","source":"Crossref","is-referenced-by-count":27,"title":["Bacterial Infections and Their Antibiotic Resistance Pattern in Ethiopia: A Systematic Review"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-0776","authenticated-orcid":true,"given":"Alemayehu","family":"Reta","sequence":"first","affiliation":[{"name":"Debre Markos University, College of Health Sciences, Department of Medical Laboratory Science, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-0331","authenticated-orcid":true,"given":"Abebaw","family":"Bitew Kifilie","sequence":"additional","affiliation":[{"name":"Debre Markos University, 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