{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:13:31Z","timestamp":1740165211164,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2019,1,20]]},"abstract":"<jats:p>Necrotizing fasciitis (NF) is a rare infection that spreads rapidly along the subcutaneous soft tissue planes. NF rarely involves the periorbital region due to the excellent blood supply of this region. We report a case of periorbital necrotising fasciitis following herpes zoster (HZ) in an immunocompromised 70-year-old patient with a dramatically rapid evolution into septic shock. In our patient, the surprisingly rapid spread of the bacterial superinfection led the periorbital cellulitis to turn into frank NF within 2 hours, with an overwhelming evolution. Despite the prompt start of a systemic antibiotic therapy and the immediate surgical intervention, the patient had a septic shock; she was treated in ITU for 31 days and then discharged to a medical ward and eventually died for a mix of complications of the medical treatment and comorbidities. This case is unique because any documented cases of periorbital NF triggered by HZ had never led to a septic shock and death. Ophthalmologists should be aware that even common skin lesions caused by shingles can determine a dramatic clinical picture, in presence of predisposing factors.<\/jats:p>","DOI":"10.1155\/2019\/4534153","type":"journal-article","created":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T23:31:18Z","timestamp":1548027078000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Necrotizing Fasciitis Following Herpes Zoster Ophthalmicus in an Immunocompromised Patient"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-5550","authenticated-orcid":true,"given":"Grazia Maria","family":"Cozzupoli","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Gui","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. 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