{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T20:22:37Z","timestamp":1750018957878,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,8,22]]},"abstract":"<jats:p>Human herpesvirus 8 (HHV-8), also known as Kaposi\u2019s sarcoma-associated herpesvirus, is a DNA oncovirus known for its role in the development of Kaposi\u2019s sarcoma (KS) and several lymphoproliferative disorders (LPDs). HHV-8 promotes lymphoproliferation via the activation of the interleukin-6 receptor signaling pathway, as well as a host of other regulatory mechanisms. The spectrum of HHV-8-associated LPDs is increasing. The World Health Organization has recently updated the classification of HHV-8-associated LPDs by introducing HHV-8-positive germinotropic LPD (GLPD) in addition to the previously recognized entities of HHV-8-positive diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), primary effusion lymphoma (PEL), and HHV-8-positive multicentric Castleman\u2019s disease (MCD). We present here a case of an HIV-positive woman with a history of KS, who later developed three HHV-8-associated LPDs, including HHV-8-positive MCD, PEL, and GLPD. To the best of our knowledge, this is the first reported case of a patient with this combination of individually rare HHV-8-associated LPDs. This case illustrates the spectrum and the sequential development of the different clinical manifestations of HHV-8-associated diseases. Detection of HHV-8 can have clinical significance in the diagnosis and management of certain HHV-8-associated conditions. Recently discovered variants of HHV-8-associated LPDs indicate that this group represents a diverse spectrum of disorders, whose classification may require further refinement beyond the currently recognized entities.<\/jats:p>","DOI":"10.1155\/2019\/4536157","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T19:31:11Z","timestamp":1566502271000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-3641","authenticated-orcid":true,"given":"Carlo","family":"Guerrero","sequence":"first","affiliation":[{"name":"Department of Medicine, Houston Methodist Hospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Jain","sequence":"additional","affiliation":[{"name":"Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Kelemen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.32.6.340"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199815000-00019"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"year":"2017","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpuli3w6wuggpy"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.233"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/his.13428"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v97.7.2130"},{"issue":"12","key":"9","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1182\/blood.V93.12.4034","volume":"93","year":"1999","journal-title":"Blood"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.2.649"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074883"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2730"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308016101"},{"issue":"7","key":"14","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1182\/blood.V96.7.2537","volume":"96","year":"2000","journal-title":"Blood"},{"first-page":"91","volume-title":"Kaposi\u2019s sarcoma-associated herpesvirus: epidemiology and molecular biology","year":"2017","key":"15"},{"issue":"7","key":"16","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1182\/blood.V88.7.2648.bloodjournal8872648","volume":"88","year":"1996","journal-title":"Blood"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.06.020"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917745584"},{"year":"2019","key":"19"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0487"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.07.084"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4536157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4536157.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4536157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T18:53:13Z","timestamp":1575571993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/4536157\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":21,"alternative-id":["4536157","4536157"],"URL":"https:\/\/doi.org\/10.1155\/2019\/4536157","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2019,8,22]]}}}