{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:02:41Z","timestamp":1789016561021,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,5,6]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To report the first case in Togo of Biermer\u2019s disease associated with intrauterine growth retardation (IUGR) in a 39-year-old pregnant woman. <jats:italic>Observation<\/jats:italic>. The patient with phenotype AA, born on 20\/02\/1978, G<jats:sub>2<\/jats:sub>P<jats:sub>0<\/jats:sub> (a spontaneous abortion at 3\u2009months), was referred to hematology on 17<jats:sup>th<\/jats:sup> March 2017 for anemia at 26\u2009weeks of amenorrhea (WA). She had received martial treatment with ferrous fumarate 66\u2009milligrams daily. At 26\u2009weeks, the uterine height was 16\u2009centimeters, and there was good fetal vitality. During ultrasound, there was a harmonious development of the fetus, but it was lower than that for the gestational age at 10<jats:sup>th<\/jats:sup> percentile based on fetal biometry, and anemia was at 65\u2009g\/l. She was then referred to hematology where she was found to have pancytopenia with macrocytic aregenerative anemia at 47\u2009g\/l (MCV at 109\u2009fl), neutropenia at 1.02\u2009g\/l, and thrombocytopenia at 58\u2009g\/l. The myelogram found megaloblastosis at 53%, collapsed serum B12 vitamin at 61.7\u2009pg\/ml, normal serum folate at 9.9\u2009ng\/ml, increased serum homocysteine to 51.44\u2009<jats:italic>\u03bc<\/jats:italic>mol\/l, and elevated LDH. The search for intrinsic anti-factor antibodies was positive. Digestive endoscopy noted fundal atrophy. The patient was given vitamin B12 injection; at the 7<jats:sup>th<\/jats:sup> day, hemoglobin was observed at 94\u2009g\/l, then a normalization of the blood count after 3\u2009weeks, and a good evolution of the pregnancy with delivery at 38\u2009WA of a newborn, female, weighing 1960\u2009g with 500\u2009grams of placenta, with a size of 40\u2009cm, and a cranial perimeter of 29\u2009cm. The child had stunted weight growth (at 16\u2009months; weight\u2009=\u20097\u2009kg; height\u2009=\u200969\u2009cm). <jats:italic>Conclusion.<\/jats:italic> Biermer\u2019s disease as a maternal cause of IUGR and infantile hypotonia is a reality in Togo. It requires management in patients and especially during pregnancy to avoid neurological complications in children born from mothers with this disease.<\/jats:p>","DOI":"10.1155\/2019\/4539675","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T14:39:44Z","timestamp":1557239984000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Intrauterine Growth Retardation Complicated by Biermer\u2019s Disease: An Observation in Togo"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-2938","authenticated-orcid":true,"given":"Essohana","family":"Padaro","sequence":"first","affiliation":[{"name":"Hematology Department, Campus Teaching Hospital, University of Lome, Lome, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baguilane","family":"Douaguibe","sequence":"additional","affiliation":[{"name":"Gynecology Department, Campus Teaching Hospital, University of Lome, Lome, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kossi","family":"Agb\u00e9tiafa","sequence":"additional","affiliation":[{"name":"Hematology Department, Campus Teaching Hospital, University of Lome, Lome, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-4917","authenticated-orcid":true,"given":"Ir\u00e9n\u00e9e","family":"Kueviakoe","sequence":"additional","affiliation":[{"name":"Hematology Department, Tokoin Teaching Hospital, University of Lome, Lome, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahoefa","family":"Vovor","sequence":"additional","affiliation":[{"name":"Hematology Department, Tokoin Teaching Hospital, University of Lome, Lome, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1415-z_2017"},{"key":"2","volume-title":"An\u00e9mies macrocytaires carentielles","year":"2002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2005.04.036"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-286"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2013.09.016"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-11-7"},{"issue":"4","key":"7","first-page":"211","volume":"5","year":"2015","journal-title":"Iranian Journal of Pediatric Hematology Oncology"},{"issue":"3","key":"8","first-page":"34","volume":"32","year":"2017","journal-title":"Mali Medical Tome"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2006.10.319"},{"issue":"1","key":"10","first-page":"13","volume":"16","year":"2010","journal-title":"Revue Critique de la Litt\u00e9rature mt"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132306"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-2115(00)00282-7"},{"key":"13"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2015.10.078"},{"issue":"3","key":"15","first-page":"325","volume":"60","year":"2002","journal-title":"Annales de Biologie Clinique"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4539675.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4539675.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4539675.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T14:39:46Z","timestamp":1557239986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/4539675\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":15,"alternative-id":["4539675","4539675"],"URL":"https:\/\/doi.org\/10.1155\/2019\/4539675","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]}}}