{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:17:41Z","timestamp":1776327461144,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Suzhou Science and Technology Bureau","award":["SYS2018005"],"award-info":[{"award-number":["SYS2018005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,6,12]]},"abstract":"<jats:p>Posterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation and migration of multiple types of cancer cells. Here, we discovered that FEZF1-AS1 is markedly upregulated in TGF-<jats:italic>\u03b2<\/jats:italic>2-treated SRA01\/04\u2009cells. In addition, the proliferation and migration of SRA01\/04\u2009cells were enhanced following TGF-<jats:italic>\u03b2<\/jats:italic>2 treatment. FEZF1-AS1 knockdown inhibited the TGF-<jats:italic>\u03b2<\/jats:italic>2-induced proliferation and migration of SRA01\/04\u2009cells. Accordingly, FEZF1-AS1 overexpression promoted the TGF-<jats:italic>\u03b2<\/jats:italic>2-induced proliferation and migration of SRA01\/04\u2009cells. Finally, FEZF1-AS1 upregulated TGF-<jats:italic>\u03b2<\/jats:italic>2-induced SRA01\/04\u2009cell proliferation and migration via boosting FEZF1 protein levels. Our findings indicate that the dysregulation of FEZF1-AS1 participates in the TGF-<jats:italic>\u03b2<\/jats:italic>2-induced proliferation and migration of human lens epithelial cells (HLECs), which might be achieved, at least in part, through the induction of FEZF1 expression.<\/jats:p>","DOI":"10.1155\/2019\/4736203","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T19:31:29Z","timestamp":1560367889000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["LncRNA FEZF1-AS1 Promotes TGF-<i>\u03b2<\/i>2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01\/04"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-9486","authenticated-orcid":true,"given":"Yong","family":"Wang","sequence":"first","affiliation":[{"name":"Aier School of Ophthalmology, Central South University, Changsha, Hunan, 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