{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:54:57Z","timestamp":1764305697340,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["10802053","31570952","7152022"],"award-info":[{"award-number":["10802053","31570952","7152022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["10802053","31570952","7152022"],"award-info":[{"award-number":["10802053","31570952","7152022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["10802053","31570952","7152022"],"award-info":[{"award-number":["10802053","31570952","7152022"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:p>Pupil blocking force (PBF) can indicate the potential risk of pupil block (PB), which is considered as a main pathogenic factor of primary angle-closure glaucoma (PACG). However, the effect of PB on the PBF under different pupil diameters and iris-lens channel (ILC) distance was unknown. Besides, a simple and practical method to assess PBF has not been reported yet. In this study, 21 finite element models of eyes with various pupil diameters (2.4\u2009mm\u20132.6\u2009mm) and ILC (2\u2009<jats:italic>\u03bc<\/jats:italic>m\u201320\u2009<jats:italic>\u03bc<\/jats:italic>m) were constructed and were conducted to simulate aqueous humor flow by fluid-solid coupling numerical simulation. PBF in each model was calculated based on the numerical simulation results and was fitted using response surface methodology. The results demonstrated that ILC distance had a more significant effect than pupil diameter on PBF. With the decrease of ILC distance, the PBF increased exponentially. When the reduced distance was lower than 5\u2009<jats:italic>\u03bc<\/jats:italic>m, the PBF exploded quickly, resulting in a high risk of iris bomb. The PBF also varied with pupil diameter, especially under the condition of narrow ILC. Both ILC distance and pupil diameter could explain more than 97% variation in PBF, and a second-order empirical model has been developed to be a good predictor of PBF. Based on the linear relationship between anterior chamber deformation and PBF, a threshold value of PBF was given to guide clinical decisions. This study could be used to investigate PACG pathological correlation and its pathogenesis, so as to provide a reference value for clinical diagnosis of PACG.<\/jats:p>","DOI":"10.1155\/2019\/4820167","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T19:30:33Z","timestamp":1569439833000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["Computational Study on the Biomechanics of Pupil Block Phenomenon"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-5663","authenticated-orcid":true,"given":"Wenjia","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing, China"},{"name":"Beijing Tiantan Hospital, Capital Medical University, Beijing, 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