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This extract reduced NO production and mRNA expression of inflammatory cytokines such as iNOS, COX-2, IL-6, and IL-1<jats:italic>\u03b2<\/jats:italic>. In the NF-<jats:italic>\u03ba<\/jats:italic>B- and AP-1-mediated luciferase reporter gene assay, transcription factor activities decreased under cotransfection with MyD88 or TRIF. Phosphorylated protein levels of Src, PI3K, IKK<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b2<\/jats:italic>, and I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic> as well as p50 and p65 in the NF-<jats:italic>\u03ba<\/jats:italic>B signal pathway were downregulated, and phosphorylation of TAK1, MEK1\/2, MKK4\/7, and MKK3\/6 as well as ERK, JNK, and p38 was decreased in the AP-1 signal pathway. Through overexpression of HA-Src and HA-TAK1, respectively, Lm-ME inhibited autophosphorylation of overexpressed proteins and thereby activated fewer downstream signaling molecules. Lm-ME also attenuated stomach ulcers in an HCl\/EtOH-induced acute gastritis model mice, and COX-2 mRNA expression and phosphorylated TAK1 levels in gastric tissues were diminished. The flavonoids kaempferol and quercetin were identified in the HPLC analysis of Lm-ME; both are actively anti-inflammatory. Therefore, these results suggest that Lm-ME can be used for anti-inflammatory remedy by targeting Src and TAK1.<\/jats:p>","DOI":"10.1155\/2019\/4873870","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T19:30:46Z","timestamp":1568316646000},"page":"1-13","source":"Crossref","is-referenced-by-count":12,"title":["Anti-Inflammatory Effects of <i>Licania macrocarpa<\/i> Cuatrec Methanol Extract Target Src- and TAK1-Mediated Pathways"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5427-386X","authenticated-orcid":true,"given":"Kon Kuk","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-6132","authenticated-orcid":true,"given":"Jae Gwang","family":"Park","sequence":"additional","affiliation":[{"name":"Department 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