{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:24:37Z","timestamp":1784287477156,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tirunelveli Medical College"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2019,7,21]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Hashimoto\u2019s thyroiditis (HT) is a common autoimmune thyroid disorder, which predominantly presents as a diffuse goiter, with few studies which report HT presenting as multinodular goiter, with variable frequencies ranging from 59% to 78.6% especially from south Indian populations. This variant clinical presentation may have diagnostic challenges which require further analysis. Anti-TPO antibodies are more common (90-95%) in Hashimoto\u2019s thyroiditis than anti-TG antibodies in Hashimoto\u2019s thyroiditis. This study analyzes the clinical features and the correlation of anti-TPO levels with diffuse and multinodular forms of HT.<jats:italic> Material and Methods<\/jats:italic>. This study was conducted in the Department of General Surgery in a tertiary care hospital in south Tamil Nadu. Patients presenting with clinical features of a thyroid disorder were interviewed and given a detailed clinical, radiological examination and guided FNAC. Those patients diagnosed by FNAC as HT were registered and a sample of 3cc of blood was drawn for T3, T4, TSH, and anti-TPO analysis. All the data were tabulated.<jats:italic> Results and Discussion<\/jats:italic>. Of the 212 patients who presented with goiters, 96 were diagnosed by FNAC as having a cytological picture suggestive of Hashimoto\u2019s thyroiditis. Of these 96 patients with HT, 46 (47.9%) were multinodular (HT-MNG), 14 (14.58%) were solitary nodules (HT-SNT), and the remaining 36 (37.5%) were diffuse goiters (HT-D). Of the 46 patients who are HT-MNG, 36.9% had elevated anti-TPO-Ab (more than 35.0U\/l) and 63.1% had normal\/lower values (less than 35.0U\/l). But of 36 patients with HT-D, 77.7% had elevated anti-TPO-Ab levels (&gt;35U\/l). Chi square statistics was 15.8346 and the p value is 0.0005 (&lt;.05). Eight cases of HT-D and 3 cases of HT-MNG had hyperthyroidism and 3 cases of HT-D had hypothyroidism and all other cases were in euthyroid state.<jats:italic> Conclusion<\/jats:italic>. Patients presenting as multinodular Hashimoto\u2019s thyroiditis have low prevalence of elevated anti-TPO-Ab than diffuse HT which suggests that multinodular form of Hashimoto\u2019s thyroiditis is a unique clinical entity with etiopathogenesis that is at variance with the diffuse form.<\/jats:p>","DOI":"10.1155\/2019\/4892329","type":"journal-article","created":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T19:30:43Z","timestamp":1563737443000},"page":"1-5","source":"Crossref","is-referenced-by-count":12,"title":["Antithyroid Peroxidase Antibodies in Multinodular Hashimoto\u2019s Thyroiditis Indicate a Variant Etiology"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-8171","authenticated-orcid":true,"given":"Pabithadevi B.","family":"Mehanathan","sequence":"first","affiliation":[{"name":"General Surgery, Tirunelveli Medical College, Tirunelveli, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Raskin","family":"Erusan","sequence":"additional","affiliation":[{"name":"Multi Disciplinary Research Unit, Tirunelveli Medical College, Tirunelveli, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-6827","authenticated-orcid":true,"given":"K.","family":"Shantaraman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tirunelveli Medical College, Tirunelveli, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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