{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:49:09Z","timestamp":1787237349451,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,1,6]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Tongxieyaofang (TXYF), a prescription originated from traditional Chinese medicine (TCM), has been widely used on treating Diarrhea Predominant Irritable Bowel Syndrome (IBS-D). The purpose of this meta-analysis was to investigate whether TXYF was effective and safe for IBS-D.\n                    <jats:italic>Methods.<\/jats:italic>\n                    We searched seven electronic databases including CENTRAL, MEDLINE, PubMed, CNKI, VIP, CBM, and Wanfang Data up to 26 July 2017. Randomized controlled trails (RCTs) were eligible, regardless of blinding. Risk of bias of included trials was evaluated according to the Cochrane Handbook.\n                    <jats:italic>Results.<\/jats:italic>\n                    The total number of participants analyzed in the meta-analysis was 3062, of which 1556 received TXYF, while 1506 received ordinary treatment. The primary outcome was clinical effective rate. Compared with conventional medication which included probiotics, pinaverium bromide, trimebutine, and Oryzanol, TXYF significantly improved the clinical effective rate (n=37, OR: 4.61; 95% CI: 3.67\u20135.78; P &lt; 0.00001) and decreased the adverse events (n=10, OR: 0.26; 95% CI: 0.08\u20130.86; P = 0.03). There was not significant association with the score of abdominal pain, defecating frequency, fecal property, and total symptom.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    We suggested a moderate recommendation for TXYF on IBS-D, due to the fact that the risk of bias of the finally included trails was not high. Considering that all identified studies were not of high qualities and large samples, further rigorously designed and large scale RCTs were necessary to improve the applicability of our study results.\n                  <\/jats:p>","DOI":"10.1155\/2019\/4893876","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T18:32:45Z","timestamp":1546799565000},"page":"1-11","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Effects and Safety of Tongxieyaofang on Diarrhea Predominant Irritable Bowel Syndrome: A Meta-Analysis of Randomized Trails"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-9086","authenticated-orcid":true,"given":"Yuhong","family":"Zhou","sequence":"first","affiliation":[{"name":"Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China"},{"name":"Department of Digestive endoscopy, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-2231","authenticated-orcid":true,"given":"Shutang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Digestive endoscopy, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1607547"},{"issue":"11","key":"2","first-page":"1393","volume":"24","year":"2015","journal-title":"Chinese Journal of Gastroenterology and 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