{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:06:21Z","timestamp":1784775981473,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2019,1,30]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The aim of this study was to assess ocular and mucocutaneous sequelae among SJS\/TEN survivors and identify risk factors of ocular sequelae.<jats:italic> Patients and Method<\/jats:italic>. Late complications among SJS\/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone.<jats:italic> Results<\/jats:italic>. Between January 1995 and December 2017, 177 cases of SJS\/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS\/TEN overlap) were admitted into two university hospitals of Lom\u00e9 (Togo). There were 113 women and 64 men, with an average age of 31.7\u00b113.0 years (range: 5 to 80 years). The most used drugs were antibacterial sulfonamides (35.6%) and nevirapine (24.3%). HIV serology was positive in 68 (59.1%) of the 115 patients tested. Sixty-four (52,5%) of the 122 patients, who had been examined by an ophthalmologist during the acute stage, had acute ocular involvement, which was mild in 27.9% of patients, moderate in 13.1%, and severe in 11.5%. We recorded 17 deaths (i.e., three cases of SJS, 12 of TEN, and two of SJS\/TEN overlap), including 11 cases of HIV infected patients. Of the 160 SJS\/TEN survivors, only 71 patients were assessed 6 months after hospital discharge. Among them, forty-three (60.6%) patients had sequelae. Concerning mucocutaneous sequelae, the main lesions were diffuse dyschromic macules (38.0% of patients) and ocular sequelae were dominated by decreased visual acuity (14.1% of patients). In multivariate analysis, exposure to sulfadoxine (odds adjusted ratio = 5.95; 95%CI= [1.36-31.35]) and moderate (adjusted odds ratio = 5.85; 95%CI = [1.23-31.81]) or severe (adjusted odds ratio = 48.30; 95%CI = [6.25-1063.66]) ocular involvement at acute stage were associated with ocular sequelae.<jats:italic> Conclusion<\/jats:italic>. Ocular and mucocutaneous sequelae are common in SJS\/TEN survivors. Exposure to sulfadoxine and severity of acute ocular involvement are risk factors of ocular sequelae.<\/jats:p>","DOI":"10.1155\/2019\/4917024","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T18:34:58Z","timestamp":1548873298000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8889-2693","authenticated-orcid":true,"given":"Bayaki","family":"Saka","sequence":"first","affiliation":[{"name":"Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abla S\u00e9fako","family":"Akakpo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julienne Noude","family":"Teclessou","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Campus Teaching Hospital, University of Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garba","family":"Mahamadou","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abas","family":"Mouhari-Toure","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Kara Teaching Hospital, University of Kara Ophthalmology, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kossi","family":"Dzidzinyo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lom\u00e9, Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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