{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:05Z","timestamp":1787017745602,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,12,9]]},"abstract":"<jats:p>\n                    <jats:italic>Background. Stenotrophomonas maltophilia<\/jats:italic>\n                    bacteremia (SMB) is the most perilous situation as compared to other types of\n                    <jats:italic>S. maltophilia<\/jats:italic>\n                    infection. The present study aimed to investigate the clinical features, distribution, drug resistance, and predictors of survival of SMB in a tertiary-care hospital of China.\n                    <jats:italic>Methods<\/jats:italic>\n                    . SMB that occurred in a tertiary-care hospital in Beijing, China, within 9\u2009years (2010\u20132018) was investigated in a retrospective study. Demographics, incidence, commodities, drug resistance, mortality, as well as antibiotics administration were summarized according to the electronic medical records. The risk factors for survival were analyzed by Chi-square test, Kaplan\u2013Meier curve and Cox regression.\n                    <jats:italic>Results<\/jats:italic>\n                    . A total of 76 episodes of SMB were analyzed. The overall incidence of SMB fluctuated from 3.4 to 15.4 episodes per 1000 admissions over 9\u2009years. Malignancy was the most common comorbidity. High\n                    <jats:italic>in vitro<\/jats:italic>\n                    sensitivity was observed to minocycline (96.1%), levofloxacin (81.6%), and trimethoprim-sulfamethoxazole (89.5%). Central venous catheter (CVC) (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.004<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), mechanical ventilation (MV) (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.006<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), hemodialysis (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.024<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), and septic shock (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.016<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ) were significantly different between survival and death group. The 30-day mortality was 34.2% within 30\u2009days after confirmation of blood culture. Factors such as hemodialysis (OR 0.287, 95% CI: 0.084\u20130.977,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.046<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), T-tube (OR 0.160, 95% CI: 0.029\u20130.881,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.035<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), and septic shock (OR 0.234, 95% CI: 0.076\u20130.719,\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.011<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ) were associated with survival.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    <jats:bold>.<\/jats:bold>\n                    <jats:italic>S. maltophilia<\/jats:italic>\n                    is the major nosocomial blood stream infectious pathogenic bacteria. Trimethoprim-sulfamethoxazole and minocycline are optimal antibiotics for the treatment of SMB. T-tube, hemodialysis, and septic shock were the risk factors associated with survival of SMB patients.\n                  <\/jats:p>","DOI":"10.1155\/2019\/4931501","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T18:31:45Z","timestamp":1575916305000},"page":"1-7","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Features, Outcomes, and Risk Factors of Bloodstream Infections due to\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    in a Tertiary-Care Hospital of China: A Retrospective Analysis"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-2297","authenticated-orcid":true,"given":"Yibing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-3586","authenticated-orcid":true,"given":"Jijiang","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Infection Management and Disease Control, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Infection Management and Disease Control, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6787-5886","authenticated-orcid":true,"given":"Yunxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infection Management and Disease Control, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-3088","authenticated-orcid":true,"given":"Zhixin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, 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