{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:43Z","timestamp":1740164563885,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["AZV CR 16-31092A"],"award-info":[{"award-number":["AZV CR 16-31092A"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth of the Czech Republic","award":["AZV CR 16-31092A"],"award-info":[{"award-number":["AZV CR 16-31092A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,3,5]]},"abstract":"<jats:p>Chronic benign CD8+ proliferation is a rare syndrome that can take the form of a variety of other diseases. Peripheral adenopathy, cytopenia, and infiltration of the liver, kidneys, bowels, or other organs are the most common clinical presentations of the syndrome. CD8+ expansion can be clonal and nonclonal. It generally occurs in patients with innate or acquired immunodeficiency (HIV+) or in patients receiving immunosuppressive therapy. It has been found repeatedly in patients who developed severe hypogammaglobulinemia after treatment with rituximab. Diagnosis of the disease can be difficult because it can mimic relapse of a lymphoma, and a common biopsy examination cannot identify the problem at first. The authors describe a case of a patient pretreated with rituximab who developed agammaglobulinemia and peripheral adenopathy. Biopsy of an enlarged lymph node showed \u201creactive lymphadenitis.\u201d Additionally, a flow-cytometric examination revealed a pathological population of CD8+ lymphocytes. The treatment, which differed from treatments of lymphoma relapse, consisted of corticosteroids and IVIG substitutions and has led to a regression of clinical symptoms. With more frequent usage of rituximab, one can expect increased occurrence of a very rare CD8+ expansion that can reliably emulate the relapse of a lymphoma.<\/jats:p>","DOI":"10.1155\/2019\/4932616","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T19:03:08Z","timestamp":1551812588000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Benign CD8+ Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7003-3559","authenticated-orcid":true,"given":"Marcela","family":"Osovsk\u00e1","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Jan\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo\u0161","family":"K\u0159en","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mare\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091505"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00445"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199601000-00017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/coh.0000000000000086"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.3.177"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.01.010"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinim.2013.05.004"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00428-015-1862-0","volume":"467","year":"2015","journal-title":"Virchows Archiv"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds517"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.786698"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23372"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.11.011"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500473113"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.839787"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0528-6"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4932616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4932616.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/4932616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T19:03:11Z","timestamp":1551812591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/4932616\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":15,"alternative-id":["4932616","4932616"],"URL":"https:\/\/doi.org\/10.1155\/2019\/4932616","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2019,3,5]]}}}