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We reported that glucagon-like peptide-1 (GLP-1) secretion in response to an oral glucose load <jats:italic>in vivo<\/jats:italic> and high-glucose stimulation <jats:italic>in vitro<\/jats:italic> was decreased by acute 3DG administration. In this study, we determined the acute effect of 3DG on GLP-1 secretion under basal conditions and investigated the possible mechanisms. Normal fasting rats were given a single acute intragastric administration of 50\u2009mg\/kg 3DG. Plasma basal GLP-1 levels and duodenum 3DG content and sweet taste receptor expression were measured. STC-1 cells were acutely exposed to 3DG (80, 300, and 1000\u2009ng\/ml) for 1\u2009h under basal conditions (5.6\u2009mM glucose), and GLP-1 secretion, intracellular concentrations of cyclic adenosine monophosphate (cAMP) and Ca<jats:sup>2+<\/jats:sup>, and molecular expression of STR signaling pathway were measured. Under the fasted state, plasma GLP-1 levels, duodenum 3DG content, and duodenum STR expression were elevated in 3DG-treated rats. GLP-1 secretion was increased in 3DG-treated cells under either 5.6\u2009mM glucose or glucose-free conditions. 3DG-induced acute GLP-1 secretion from STC-1 cells under 5.6\u2009mM glucose was inhibited in the presence of the STR inhibitor lactisole, which was consistent with the observation under glucose-free conditions. Moreover, acute exposure to 3DG increased the protein expression of TAS1R2 and TAS1R3 under either 5.6\u2009mM glucose or glucose-free conditions, with affecting other components of STR signaling pathway, including the upregulation of transient receptor potential channel type M5 TRPM5 and the increment of intracellular Ca<jats:sup>2+<\/jats:sup> concentration. In summary, the glucose-free condition was used to first demonstrate the involvement of STR in 3DG-induced acute GLP-1 secretion. These results first showed that acute 3DG administration induces basal GLP-1 secretion in part through upregulation of STR expression.<\/jats:p>","DOI":"10.1155\/2019\/4959646","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T19:30:43Z","timestamp":1571859043000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1615-7996","authenticated-orcid":true,"given":"Xiudao","family":"Song","sequence":"first","affiliation":[{"name":"Clinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, Jiangsu, China"},{"name":"Clinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou Academy of Wumen 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