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Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization\/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3\u2009ppm). Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes. Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls. Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen\u2019s disease, and kidney, liver, bladder, and lung cancer).<\/jats:p>","DOI":"10.1155\/2019\/4978018","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T19:30:27Z","timestamp":1571167827000},"page":"1-17","source":"Crossref","is-referenced-by-count":36,"title":["Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-2299","authenticated-orcid":true,"given":"Cesar","family":"Rivas-Santiago","sequence":"first","affiliation":[{"name":"CONACyT, Unidad Acad\u00e9mica de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Zacatecas, Zacatecas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Gonz\u00e1lez-Curiel","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Ciencia y Tecnolog\u00eda Qu\u00edmica, Unidad Acad\u00e9mica de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Zacatecas, Zacatecas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Zarazua","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurotoxicolog\u00eda, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Murgu","sequence":"additional","affiliation":[{"name":"Waters Technologies of Brazil, Barueri, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alonso","family":"Ruiz Cardona","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurotoxicolog\u00eda, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Lazalde","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Ciencia y Tecnolog\u00eda Qu\u00edmica, Unidad Acad\u00e9mica de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Zacatecas, Zacatecas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-3233","authenticated-orcid":true,"given":"Edgar E.","family":"Lara-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica de Zacatecas, Instituto Mexicano de Seguro Social, Zacatecas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Waters Corporation, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Enrique","family":"Casta\u00f1eda-Delgado","sequence":"additional","affiliation":[{"name":"Catedr\u00e1tico-CONACYT, Unidad de Investigaci\u00f3n Biom\u00e9dica de Zacatecas-IMSS. 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