{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:32:57Z","timestamp":1784824377823,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2019,5,6]]},"abstract":"<jats:p><jats:italic>Granulicatella adiacens<\/jats:italic> and <jats:italic>Abiotrophia defectiva<\/jats:italic> are an increasingly recognized cause of osteoarticular infections. We describe two cases of <jats:italic>G. adiacens<\/jats:italic> and one case of <jats:italic>A. defectiva<\/jats:italic> native vertebral osteomyelitis (NVO) and review all published cases. Nine cases of <jats:italic>G. adiacens<\/jats:italic> NVO and two cases of <jats:italic>A. defectiva<\/jats:italic> NVO were previously described. Patients were usually middle-aged men, and classical risk factors for NVO were present in half of the cases. Concomitant bacteremia was reported in 78.6% of cases, and concurrent infective endocarditis occurred in 36.4% of this sub-group of patients. Many different antibiotic schemes were recorded, with median treatment duration of 6\u2009weeks. In the most recent reports, glycopeptides represented the most frequent empirical therapy, possibly due to the increasing emergence of <jats:italic>G. adiacens<\/jats:italic> and <jats:italic>A. defectiva<\/jats:italic> penicillin-resistant strains. Stabilization surgery was rarely required (14.3% of cases), and clinical cure was generally achieved. In conclusion, <jats:italic>Granulicatella spp<\/jats:italic>. and <jats:italic>Abiotrophia spp<\/jats:italic>. NVO is rare but increasingly described. A total antibiotic course of six weeks seems to be appropriate for noncomplicated cases, and clinical outcome is generally favorable.<\/jats:p>","DOI":"10.1155\/2019\/5038563","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T14:47:50Z","timestamp":1557240470000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["<i>Granulicatella adiacens<\/i> and <i>Abiotrophia defectiva<\/i> Native Vertebral Osteomyelitis: Three Cases and Literature Review of Clinical Characteristics and Treatment Approach"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-1341","authenticated-orcid":true,"given":"Cinzia","family":"Puzzolante","sequence":"first","affiliation":[{"name":"Azienda Ospedaliero-Universitaria di Modena, Infectious Disease Clinic, Modena, 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