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Ca<jats:sup>2+<\/jats:sup> regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity. <jats:italic>Method<\/jats:italic>. A well-established rat model of high repetition high force (HRHF) work was used to investigate if such exposure leads to an increase in cytosolic Ca<jats:sup>2+<\/jats:sup> concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>) and changes in sarcoplasmic reticulum (SR) vesicle Ca<jats:sup>2+<\/jats:sup> uptake and release rates. <jats:italic>Result<\/jats:italic>. Six weeks exposure of rats to HRHF increased indicators of fatigue, pain behaviors, and [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, the latter implied by around 50\u2013100% increases in pCam, as well as in the Ca<jats:sup>2+<\/jats:sup> handling proteins RyR1 and Casq1 accompanied by an \u223c10% increased SR Ca<jats:sup>2+<\/jats:sup> uptake rate in extensor and flexor muscles compared to those of control rats. This demonstrated a work-related altered myocellular Ca<jats:sup>2+<\/jats:sup> regulation, SR Ca<jats:sup>2+<\/jats:sup> handling, and SR protein expression. <jats:italic>Discussion<\/jats:italic>. These disturbances may mirror intracellular changes in early stages of human work-related myalgic muscle. Increased uptake of Ca<jats:sup>2+<\/jats:sup> into the SR may reflect an early adaptation to avoid a sustained detrimental increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> similar to the previous findings of deteriorated Ca<jats:sup>2+<\/jats:sup> regulation and impaired function in fatigued human muscle.<\/jats:p>","DOI":"10.1155\/2019\/5040818","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T21:43:40Z","timestamp":1569879820000},"page":"1-14","source":"Crossref","is-referenced-by-count":15,"title":["Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-7842","authenticated-orcid":true,"given":"J.","family":"Hadrevi","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicines, Occupational and Environmental Medicine, Ume\u00e5 University, 901 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-9803","authenticated-orcid":true,"given":"M. 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