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The endurance exercise is capable of inducing skeletal muscle, heart, and respiratory fatigue, evidenced by morphofunctional cardiac changes, release of myocardial injury biomarkers, and reduction of maximal voluntary ventilation and oxygen consumption (VO<jats:sub>2<\/jats:sub>) at peak exercise. <jats:italic>Purpose<\/jats:italic>. The aim of this study was to investigate whether marathoners present cardiac fatigue after marathon and whether it correlates with pulmonary levels of exhaled nitric oxide (eNO) and pulmonary inflammation. <jats:italic>Methods<\/jats:italic>. 31 male marathoners, age <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>39<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:math> years, were evaluated by cardiopulmonary exercise test three weeks before and between three and 15 days after a marathon; eNO analysis and spirometry were evaluated before, immediately after, and 24 and 72 hours after the marathon, and sputum cellularity and cytokine level were assessed before and after the marathon. <jats:italic>Results<\/jats:italic>. Marathon induced an increase in the percentage of macrophages, neutrophils (from 0.65% to 4.28% and 6.79% to 14.11%, respectively), and epithelial cells and a decrease in cytokines in induced sputum, followed by an increase in eNO concentration (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>20<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>11<\/mml:mn><\/mml:math> to <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn>35<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>19<\/mml:mn><\/mml:math>\u00a0ppb), which presented a significant reduction 24 and 72 hours after marathon (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>12<\/mml:mn><\/mml:math>\u00a0e <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>12<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:math>\u00a0ppb, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). We observed a decrease in the spirometry parameters in all time points assessed after the marathon (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) as well as in cardiopulmonary capacity, evidenced by a reduction in VO<jats:sub>2<\/jats:sub> and ventilation peaks (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn>57<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:math> to <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mn>55<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:math>\u00a0mL\u00b7min<jats:sup>-1<\/jats:sup>\u00b7Kg<jats:sup>-1<\/jats:sup> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mn>134<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>19<\/mml:mn><\/mml:math> to <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mn>132<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>18<\/mml:mn><\/mml:math>\u00a0Lpm, respectively, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Finally, we observed a negative correlation between the decrease in forced expiratory volume and decrease in eNO 24 and 72 hours after marathon (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>r<\/mml:mi><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>0.4<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. Reduction in eNO bioavailability after marathon prevents the reduction in cardiopulmonary capacity induced by acute inflammatory pattern after marathon.<\/jats:p>","DOI":"10.1155\/2019\/5134360","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T18:31:43Z","timestamp":1550428303000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-7195","authenticated-orcid":true,"given":"Ana Paula","family":"Sierra","sequence":"first","affiliation":[{"name":"School of Physical Education and Sport, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Sports Cardiology Department, Dante Pazzanese Institute of Cardiology, S\u00e3o Paulo, 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Ghorayeb","sequence":"additional","affiliation":[{"name":"Sports Cardiology Department, Dante Pazzanese Institute of Cardiology, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Augusta Peduti Dal Molin","family":"Kiss","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1596-0624","authenticated-orcid":true,"given":"Maria Fernanda","family":"Cury-Boaventura","sequence":"additional","affiliation":[{"name":"Institute of Physical Activity and Sports Sciences (ICAFE), Cruzeiro do Sul University (UNICSUL), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o 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