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System (ANS). Several illnesses have been associated with changes in the ANS, thus altering the pattern of HRV. However, the variability of the heart rhythm is originated within the Sinus Atrial Node (SAN) which has its own variability. Still, although both oscillators produce HRV, the influence of the SAN on HRV has not yet been exhaustively studied. On the other hand, the complications of diabetes mellitus (DM), for instance, nephropathy, retinopathy, and neuropathy, increase cardiovascular morbidity and mortality. Traditionally, these complications are diagnosed only when the patient is already suffering from the negative symptoms these complications implicate. Consequently, it is of paramount importance to develop new techniques for early diagnosis prior to any deterioration on healthy patients. HRV has been proved to be a valuable, noninvasive clinical evidence for evaluating diseases and even for describing aging and behavior. In this study, several ECGs were recorded and their RR and PP intervals were analyzed to detect the interpotential interval (ii) of the SAN. Additionally, HRV reduction was quantified to identify alterations in the nervous system within the nodal tissue via measuring the SD1\/SD2 ratio in a Poincar\u00e9 plot. With 15 years of DM development, the data showed an age-dependent increase in HRV due to the axon retraction of ANS neurons from its effectors. In addition, these alterations modify the heart rhythm-producing fatal arrhythmias. Therefore, it is possible to avoid the consequences of DM identifying alterations in SAN previous to its symptomatic appearance. This could be used as an early diagnosis indicator.<\/jats:p>","DOI":"10.1155\/2019\/5157024","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T19:31:40Z","timestamp":1557430300000},"page":"1-10","source":"Crossref","is-referenced-by-count":21,"title":["The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-7714","authenticated-orcid":true,"given":"Alondra","family":"Albarado-Iba\u00f1ez","sequence":"first","affiliation":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico, Centro de las Ciencias de la Complejidad, Circuito Mario de la Cueva 20, Insurgentes Sur, Delegaci\u00f3n Coyoac\u00e1n, C.P. 04510 Cd. de M\u00e9xico, Mexico"},{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Instituto de Fisiolog\u00eda, 14 Sur 6301, Colonia Jardines de San 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