{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:17:26Z","timestamp":1791839846433,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2019,3,3]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Liver diseases are a global health problem. Medicinal plants are being increasingly used to manage a wide variety of diseases including liver disorders. The aim of this study was to investigate the antioxidant properties and hepatoprotective activity of polyphenolic extract from the fruits of<jats:italic>Tetrapleura tetraptera (T. tetraptera)<\/jats:italic>.<jats:italic>Results<\/jats:italic>. The extract of<jats:italic>T. tetraptera<\/jats:italic>was administered at doses of 50 mg\/kg and 100 mg\/kg for 07<jats:italic>per os<\/jats:italic>to rats before the induction of hepatotoxicity with of 2 ml\/kg of 1:1 (v\/v) carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) and olive oil through intraperitoneal route. The<jats:italic>in vitro<\/jats:italic>antioxidant and radical scavenging properties of<jats:italic>T. tetraptera<\/jats:italic>were conducted by the FRAP method, the phosphomolybdate method, and the inhibition potential of DPPH, ABTS, OH, and NO radicals. The extraction yield of<jats:italic>T. tetraptera<\/jats:italic>was 19.35%. This extract contains polyphenols (273.48 mg CAE\/g DM), flavonoids (5.2549 mg SE\/g DM), and flavonols (1.615 mg SE\/g DM). This extract showed<jats:italic>in vitro<\/jats:italic>antioxidant activity, an inhibitor power of various free radicals, and radical scavenging potential dose-dependent. The fifty-percent inhibitory concentration of the extract (IC<jats:sub>50<\/jats:sub>) for the studied radical varied from 28.16 to 136<jats:italic>\u03bc<\/jats:italic>g\/L. In rats treated with the extract of<jats:italic>T. tetraptera<\/jats:italic>, in a dose-dependent manner, the levels of hepatotoxicity markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) significantly increased while the enzyme activities of superoxide dismutase (SOD), catalase (CAT), and the level of reduced glutathione (GHS) significantly increased compared to the control group.<jats:italic>Conclusions<\/jats:italic>. The extracts from the fruit of<jats:italic>T. tetraptera<\/jats:italic>demonstrate antioxidant activity and hepatoprotective effects.<\/jats:p>","DOI":"10.1155\/2019\/5236851","type":"journal-article","created":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T23:32:51Z","timestamp":1551655971000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["Phenolic Compounds from Water-Ethanol Extracts of<i>Tetrapleura tetraptera<\/i>Produced in Cameroon, as Potential Protectors against<i>In Vivo<\/i>CC<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">l<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>4<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>-Induced Liver Injuries"],"prefix":"10.1155","volume":"2019","author":[{"given":"Peter William Kemewele","family":"Saague","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, P.O. Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-6616","authenticated-orcid":true,"given":"Bruno","family":"Moukette Moukette","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, P.O. Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques Romain","family":"Njimou","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, University of Yaound\u00e9 I, P.O. Box 812, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper Cabral Nya","family":"Biapa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Nzufo Tankeu","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, P.O. Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky Joseline Ama","family":"Moor","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, P.O. Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-6494","authenticated-orcid":true,"given":"Constant Anatole","family":"Pieme","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, P.O. Box 1364, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne Yonkeu","family":"Ngogang","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I, P.O. 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