{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:41:25Z","timestamp":1790343685773,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2019,4,8]]},"abstract":"<jats:p><jats:italic>Background and Objective<\/jats:italic>. Type 2 DM and obesity are the coming epidemics and their association with NAFLD is well established; essential fatty acids are vital for body health yet the body cannot make them; 2 essential fatty acids are especially important: linoleic (omega-6) and alpha-linoleic (omega-3) acids; they can be considered as \u201cbioactive lipids\u201d and serve as functional foods.<jats:italic>Methods<\/jats:italic>. 50 type 2 Egyptian diabetic patients controlled on oral hypoglycemic drugs together with 20 age- and sex-matched healthy participants were enrolled in the study; all were subjected to complete history taking, BMI, fasting plasma glucose, HOMA-IR, ALT, AST, GGT, urea and creatinine, total lipid profile, hepatitis markers including hepatitis B surface antigen and hepatitis C virus antibodies, conjugated linoleic fatty acid \u201cCLA,\u201d and abdominal ultrasound for grading of NAFLD.<jats:italic>Results<\/jats:italic>. Our study in Egyptian diabetics with NAFLD revealed a low level of serum CLA compared to healthy control; such deficiency was more marked with advanced grades of NAFLD; lowest levels were observed in those with severe steatosis (NASH) with definite association between CLA and obesity.<jats:italic>Conclusion<\/jats:italic>. Insulin resistance is the main link between NAFLD, diabetes, and obesity. Conjugated linoleic acid (CLA) has a role in fat deposition in the liver and in development and improvement of insulin resistance. Fatty food had a documented role in the pathogenesis of obesity and diabetes but it can also be the cure.<\/jats:p>","DOI":"10.1155\/2019\/5267025","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T23:31:54Z","timestamp":1554766314000},"page":"1-7","source":"Crossref","is-referenced-by-count":19,"title":["Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link?"],"prefix":"10.1155","volume":"2019","author":[{"given":"Mona","family":"Hegazy","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-808X","authenticated-orcid":true,"given":"Naglaa M.","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Cairo University, 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