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Previous studies have shown that fluoride exposure damages the male reproductive function. This study aimed to evaluate the fluoride sub-chronic exposure on the spermatozoa function in streptozotocin (STZ)-induced diabetic mice. After confirming diabetes by measuring blood glucose levels, the male mice received 45.2\u2009ppm of fluoride added or deionized water. We evaluated several parameters in diabetic mice exposed to fluoride: standard quality analysis, the mitochondrial transmembrane potential (<jats:italic>\u03c8<\/jats:italic>m), the caspase activity in spermatozoa, urinary fluoride excretion, and histological evaluation in the testes. After 60 days of fluoride-exposure, diabetic mice, significantly decreased sperm quality (motility, viability, and concentration). Spermatozoa from fluoride-exposure in diabetic mice presented a significant decrease in <jats:italic>\u03c8<\/jats:italic>m and a significant increase in activity caspase 3\/7. Urinary fluoride excretion was decreased in diabetic mice exposed to fluoride. Subchronic fluoride exposure of mice with STZ-induced diabetes aggravated testicular damage and the spermatozoa function.<\/jats:p>","DOI":"10.1155\/2019\/5269380","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T18:30:35Z","timestamp":1575397835000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Exposure of Fluoride with Streptozotocin-Induced Diabetes Aggravates Testicular Damage and Spermatozoa Parameters in Mice"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-8080","authenticated-orcid":true,"given":"Manuel","family":"S\u00e1nchez-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina, Instituto de Ciencias de la Salud, Universidad Autonoma del Estado de Hidalgo, Carretera Actopan-Tilcuautla, Ex-hacienda La Concepci\u00f3n S\/N, San Agust\u00edn Tlaxiaca 42160, Hidalgo, 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