{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:35:45Z","timestamp":1747190145623,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,6,27]]},"abstract":"<jats:p>Hepatosplenic T-cell lymphomas (TCLs) are a rare, aggressive subset of TCLs, accounting for less than 5% of all peripheral T-cell and natural killer (NK) cell lymphomas. We report the case of a CD3 negative hepatosplenic T-cell lymphoma in a 42-year-old female, who presented with left-sided abdominal pain. She underwent a liver biopsy that showed marked abnormal sinusoidal lymphoid infiltration. PET scan revealed increased splenic and pharyngeal lymph node uptake. Immunophenotype was remarkable for negative CD3, gamma delta T-cell receptor, and alpha beta-T-cell receptor expression. She received 6 cycles of DA-EPOCH, had primary refractory disease and then underwent palliative splenectomy secondary to painful necrosis. Then, she was started on pralatrexate as a single agent and then in combination with romidepsin as a potential bridge to an allogeneic stem cell transplantation from her sibling.<\/jats:p>","DOI":"10.1155\/2019\/5315086","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T19:31:20Z","timestamp":1561663880000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-4094","authenticated-orcid":true,"given":"Laura","family":"Alder","sequence":"first","affiliation":[{"name":"Department of Medicine, VCU Health, 1201 E Marshall St, Richmond, VA 23298, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Graupner","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Massey Cancer Center, VCU Health, 401 College St, Richmond, VA 23298, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanhua","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathology, VCU Health, 1201 E Marshall St, Richmond, VA 23298, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Yazbeck","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Massey Cancer Center, VCU Health, 401 College St, Richmond, VA 23298, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0074-cr"},{"issue":"21","key":"2","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1182\/blood.V122.21.3032.3032","volume":"122","year":"2013","journal-title":"Blood"},{"issue":"3","key":"3","first-page":"160","volume":"11","year":"2015","journal-title":"Gastroenterology & Hepatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-396150"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0524"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0079-rs"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-017-0021-z"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.43"},{"issue":"2","key":"9","first-page":"109","volume":"11","year":"2013","journal-title":"Clinical Advances in Hematology & Oncology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0470-0"},{"issue":"2","key":"11","first-page":"113","volume":"11","year":"2013","journal-title":"Clinical Advances in Hematology & Oncology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806737"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/5315086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/5315086.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/5315086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T02:19:13Z","timestamp":1575166753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/5315086\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":12,"alternative-id":["5315086","5315086"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5315086","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2019,6,27]]}}}