{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:07:00Z","timestamp":1790492820549,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2019,8,21]]},"abstract":"<jats:p><jats:italic>Background\/Aim<\/jats:italic>. Inflammatory bowel disease (IBD) is a chronic disorder affecting patients\u2019 quality of life and increasing their disability. The aim of our study was to evaluate clinical and pharmacological factors associated with impaired quality of life and disability in a large cohort of IBD patients during IBD treatment. <jats:italic>Methods<\/jats:italic>. We consecutively and prospectively recruited all IBD patients referred to the IBD Unit of the \u201cAzienda Ospedaliera\u201d of Padua. Demographics and clinical information were collected, and all patients completed the IBD questionnaire (IBDQ) and the IBD-Disability Index (IBD-DI) questionnaire. A multivariate regression model and Spearman\u2019s rank correlation coefficient were applied for detecting IBD-related variables relevant to disability and quality of life. <jats:italic>Results<\/jats:italic>. We included 435 IBD patients. Multivariate regression modelling identified active disease, anaemia, presence of extraintestinal manifestations, and Crohn subtype as independent predictors for both disability and poor quality of life. We observed a strong positive correlation between IBD-DI and IBDQ (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.84<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), while there was no association with ongoing therapy or other clinical features disease-related. <jats:italic>Conclusions<\/jats:italic>. Our study showed that disability and quality of life are both associated with active disease, anaemia, presence of extraintestinal manifestations, and Crohn phenotype while ongoing therapy seems not to be associated with disability and QoL during disease management.<\/jats:p>","DOI":"10.1155\/2019\/5354320","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T19:48:05Z","timestamp":1566416885000},"page":"1-10","source":"Crossref","is-referenced-by-count":55,"title":["Factors Influencing Disability and Quality of Life during Treatment: A Cross-Sectional Study on IBD Patients"],"prefix":"10.1155","volume":"2019","author":[{"given":"Carla","family":"Marinelli","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":true,"given":"Edoardo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Inferrera","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Lorenzon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Rigo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ghisa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Facchin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, I-35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"D\u2019Inc\u00e0","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology 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