{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:20:43Z","timestamp":1781281243482,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","award":["STDF 5167"],"award-info":[{"award-number":["STDF 5167"]}],"id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,11,6]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Assessing the therapeutic efficacy of superparamagnetic iron oxide nanoparticles (SPIO) labeled bone marrow-derived mesenchymal stem cells (BM-MSCs) on experimental liver fibrosis and associated dysplasia. <jats:italic>Materials and Methods<\/jats:italic>. MSCs were obtained from 10 male Sprague-Dawley rats while 50 female rats were divided into control (CG), liver fibrosis (CCL4, intraperitoneal injection of CCl<jats:sub>4<\/jats:sub> for 8 weeks), and CCL<jats:sub>4<\/jats:sub> rats treated with SPIO-labeled MSCs (MSCs\/CCl<jats:sub>4<\/jats:sub>) with and without continuing CCL<jats:sub>4<\/jats:sub> injection for another 8 weeks. Assessment included liver histopathology, liver function tests, transmission electron microscopic tracing for homing of SPIO-MSCs, immunofluorescence histochemistry for fibrosis and dysplasia markers (transforming growth factor-beta (TGF-<jats:italic>\u03b2<\/jats:italic>1), proliferation nuclear antigen (PCNA), glypican 3)), and quantitative gene expression analysis for matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1). <jats:italic>Results<\/jats:italic>. SPIO-labeled MSCs were engrafted in the fibrotic liver and the BM\/MSCs demonstrated regression for fibrous tissue deposition and inhibition progression of dysplastic changes in the liver of CCl<jats:sub>4<\/jats:sub>-treated rats on both the histological and molecular levels. <jats:italic>Conclusion<\/jats:italic>. BM-MSCs possess regenerative and antidysplastic potentials.<\/jats:p>","DOI":"10.1155\/2019\/5376165","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T18:30:54Z","timestamp":1573065054000},"page":"1-15","source":"Crossref","is-referenced-by-count":19,"title":["Bone Marrow-Derived Mesenchymal Stem Cell Potential Regression of Dysplasia Associating Experimental Liver Fibrosis in Albino Rats"],"prefix":"10.1155","volume":"2019","author":[{"given":"Yasmine H.","family":"Khalifa","sequence":"first","affiliation":[{"name":"Histology and Cell Biology Department, Faculty of Medicine, Alexandria University, Dr. Fahmi Abdel Meguid Street, Mowassat Building, El Shatby, Alexandria 21561, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Mourad","sequence":"additional","affiliation":[{"name":"Histology and Cell Biology Department, Faculty of Medicine, Alexandria University, Dr. Fahmi Abdel Meguid Street, Mowassat 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