{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:20:57Z","timestamp":1782836457906,"version":"3.54.5"},"reference-count":147,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Project for Performance Incentive and Guidance of Chongqing Scientific Research Institute","award":["cstc2018jxjl130085"],"award-info":[{"award-number":["cstc2018jxjl130085"]}]},{"name":"Special Project for Performance Incentive and Guidance of Chongqing Scientific Research Institute","award":["cstc2018jcyjAX0830"],"award-info":[{"award-number":["cstc2018jcyjAX0830"]}]},{"name":"Special Project for Performance Incentive and Guidance of Chongqing Scientific Research Institute","award":["Cstc2017jcyjbx0044"],"award-info":[{"award-number":["Cstc2017jcyjbx0044"]}]},{"name":"Special Project for Performance Incentive and Guidance of Chongqing Scientific Research Institute","award":["2019CDQYGD038"],"award-info":[{"award-number":["2019CDQYGD038"]}]},{"name":"Chongqing Basic Research and Frontier Exploration Project","award":["cstc2018jxjl130085"],"award-info":[{"award-number":["cstc2018jxjl130085"]}]},{"name":"Chongqing Basic Research and Frontier Exploration Project","award":["cstc2018jcyjAX0830"],"award-info":[{"award-number":["cstc2018jcyjAX0830"]}]},{"name":"Chongqing Basic Research and Frontier Exploration Project","award":["Cstc2017jcyjbx0044"],"award-info":[{"award-number":["Cstc2017jcyjbx0044"]}]},{"name":"Chongqing Basic Research and Frontier Exploration Project","award":["2019CDQYGD038"],"award-info":[{"award-number":["2019CDQYGD038"]}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2018jxjl130085"],"award-info":[{"award-number":["cstc2018jxjl130085"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2018jcyjAX0830"],"award-info":[{"award-number":["cstc2018jcyjAX0830"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["Cstc2017jcyjbx0044"],"award-info":[{"award-number":["Cstc2017jcyjbx0044"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["2019CDQYGD038"],"award-info":[{"award-number":["2019CDQYGD038"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["cstc2018jxjl130085"],"award-info":[{"award-number":["cstc2018jxjl130085"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["cstc2018jcyjAX0830"],"award-info":[{"award-number":["cstc2018jcyjAX0830"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["Cstc2017jcyjbx0044"],"award-info":[{"award-number":["Cstc2017jcyjbx0044"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019CDQYGD038"],"award-info":[{"award-number":["2019CDQYGD038"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,11,21]]},"abstract":"<jats:p>Ultraviolet (UV) irradiation can be considered as a double-edged sword: not only is it a crucial environmental factor that can cause skin-related disorders but it can also be used for phototherapy of skin diseases. Inducible heme oxygenase-1 (HO-1) in response to a variety of stimuli, including UV exposure, is vital to maintain cell homeostasis. Heme oxygenase-2 (HO-2), another member of the heme oxygenase family, is constitutively expressed. In this review, we discuss how heme oxygenase (HO), a vital rate-limiting enzyme, participates in heme catabolism and cytoprotection. Phylogenetic analysis showed that there may exist a functional differentiation between HO-1 and HO-2 during evolution. Furthermore, depending on functions in immunomodulation and antioxidation, HO-1 participates in disease progression, especially in pathogenesis of skin diseases, such as vitiligo and psoriasis. To further investigate the particular role of HO-1 in diseases, we summarized the profile of the HO enzyme system and its related signaling pathways, such as Nrf2 and endoplasmic reticulum crucial signaling, both known to regulate HO-1 expression. Furthermore, we report on a C-terminal truncation of HO-1, which is generally considered as a signal molecule. Also, a newly identified alternative splice isoform of HO-1 not only provides us a novel perspective on comprehensive HO-1 alternative splicing but also offers us a basis to clarify the relationship between HO-1 transcripts and oxidative diseases. To conclude, the HO system is not only involved in heme catabolism but also involved in biological processes related to the pathogenesis of certain diseases, even though the mechanism of disease progression still remains sketchy. Further understanding the role of the HO system and its relationship to UV is helpful for revealing the HO-related signaling networks and the pathogenesis of many diseases.<\/jats:p>","DOI":"10.1155\/2019\/5416728","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T23:31:02Z","timestamp":1574379062000},"page":"1-17","source":"Crossref","is-referenced-by-count":55,"title":["Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress"],"prefix":"10.1155","volume":"2019","author":[{"given":"ShiDa","family":"Chen","sequence":"first","affiliation":[{"name":"The Base of \u201c111 Project\u201d for Biomechanics & Tissue Repair Engineering; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoYu","family":"Wang","sequence":"additional","affiliation":[{"name":"The Base of \u201c111 Project\u201d for Biomechanics & Tissue Repair Engineering; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Farrukh","family":"Nisar","sequence":"additional","affiliation":[{"name":"The Base of \u201c111 Project\u201d for Biomechanics & Tissue Repair Engineering; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-5833","authenticated-orcid":true,"given":"Mao","family":"Lin","sequence":"additional","affiliation":[{"name":"Chongqing Traditional Chinese Medicine Hospital, Chongqing 400011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-6824","authenticated-orcid":true,"given":"Julia Li","family":"Zhong","sequence":"additional","affiliation":[{"name":"The Base of \u201c111 Project\u201d for Biomechanics & Tissue Repair Engineering; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China"},{"name":"Chongqing Traditional Chinese Medicine Hospital, Chongqing 400011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0162-0134(00)00156-2"},{"key":"2","first-page":"181","volume-title":"Regulation and role of heme oxygenase in oxidative injury","volume":"36","year":"2001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5483\/bmbrep.2008.41.2.164"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0531-5565(00)00148-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05319.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.13.5987"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68020715.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(96)00183-2"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/604981"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105010"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.23.20.7198-7209.2003"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78031"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.00963.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077224"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a130494"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607954200"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.04.096"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05526.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.494"},{"issue":"1","key":"21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9258(17)42488-4","volume":"261","year":"1986","journal-title":"Journal of Biological Chemistry"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2004.6.835"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2004.6.924"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.020"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252626999"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2174\/138920009789375405"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.03.004"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.52.32804"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141053"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200201001-00002"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.10954"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(99)00223-3"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609065729"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080894"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.2023"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2822"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1042\/bj2190001"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)90749-8"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1213"},{"issue":"14","key":"41","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1016\/S0021-9258(18)48315-9","volume":"262","year":"1987","journal-title":"Journal of Biological Chemistry"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/s1357-2725(97)00109-x"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.10.037"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(99)00439-4"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.031"},{"key":"46","doi-asserted-by":"crossref","first-page":"S863","DOI":"10.1161\/CIRCULATIONAHA.107.760405","volume":"118","year":"2008","journal-title":"Circulation"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1801"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1089\/152308602753666370"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPT.0000012119.83734.4e"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690624"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-214-44069"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2000.tb01033.x"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802206686"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3530459"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01232.x"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/srep42394"},{"key":"57","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1038\/jid.2014.152","volume":"134","year":"2014","journal-title":"Journal of Investigative Dermatology"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.117"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13723"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.05.006"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12874"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051365"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.517"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2445"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401984"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00216-5"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00677.x"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077230"},{"issue":"5","key":"69","first-page":"405","volume":"7","year":"1990","journal-title":"Molecular Biology & Medicine"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3401-0_17"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1039\/c2pp25152c"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950180210"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1548"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(79)70018-1"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(91)80147-A"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12111"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.03.1511"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.017"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2007.00291.x"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.030"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1038\/379335a0"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04427.x"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199410000-00001"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1111\/php.12342"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1039\/C2PP25323B"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2011.v5.1.23"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.99"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.5.1103"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05222e"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1042\/bj2900343"},{"issue":"30","key":"91","doi-asserted-by":"crossref","first-page":"21894","DOI":"10.1016\/S0021-9258(19)36696-7","volume":"267","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00274.2005"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.122"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141046"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2012.10.001"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2223-0"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3112re3"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.1.76"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308347100"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1159\/000452744"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0674-5"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01204-10"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2006.01.007"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1021\/tx100389r"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.1.221-229.2006"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00358.x"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.11.6083"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.5.1733-1746.2000"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.11.002"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.20.15370"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112003200"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3867"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1038\/16729"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.22.21.7405-7416.2002"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(03)00105-9"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1489127"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.12b.2083"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400541101"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2738"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101198200"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.05.008"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.018"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3270"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1159\/000458742"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90481-b"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.6.1330"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-472"},{"key":"129","doi-asserted-by":"crossref","first-page":"L497","DOI":"10.1152\/ajplung.00100.2005","volume":"289","year":"2005","journal-title":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3125-8"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01580.x"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.03.003"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.08.005"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1162-2"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02908.x"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.05.025"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.57"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107749200"},{"key":"139","first-page":"S38","volume":"41","year":"2006","journal-title":"Free Radical Biology and Medicine"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1021\/bi972720x"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.567685"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-06-0319"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.24.7416"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.4.841"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9317"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(02)01037-0"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.18.011402.160624"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.1042\/BST20060007"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/5416728.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/5416728.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/5416728.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T23:57:17Z","timestamp":1612483037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2019\/5416728\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,21]]},"references-count":147,"alternative-id":["5416728","5416728"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5416728","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,21]]}}}