{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:05:35Z","timestamp":1778605535705,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z151100004015064"],"award-info":[{"award-number":["Z151100004015064"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2019,4,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Studies have demonstrated that liver fibrosis can be reversed by medication treatments. After splenectomy, cirrhosis patients have short-term changes in several serum markers for cirrhosis and liver stiffness. <jats:italic>Aims<\/jats:italic>. To investigate the effect of splenectomy on the severity of cirrhosis. <jats:italic>Methods<\/jats:italic>. A total of 62 patients with cirrhosis and portal hypertension receiving splenectomy from December 2014 to July 2017 were enrolled. The degree of cirrhosis was preoperatively and postoperatively evaluated by serum markers, including hyaluronan (HA), laminin, amino-terminal propeptide of type III procollagen (PIIINP), type IV collagen (C-IV), liver stiffness (FibroScan), and liver volume. <jats:italic>Results<\/jats:italic>. HA levels significantly increased at 1 week and 1 month postoperation (both <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), whereas the levels of PIIINP and C-IV significantly decreased from 1 month to 12 months postoperation (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). In addition, elastography examination demonstrated that the FibroScan score significantly reduced from 1 month to 24 months postoperation as compared with the baseline level (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). CT scan showed that the liver volume significantly increased at 6 months postoperation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Furthermore, the alteration trends of these serum markers and the FibroScan score were further confirmed by the multivariate linear regression. <jats:italic>Conclusions<\/jats:italic>. These observations suggested that splenectomy may result in long-term reversal of cirrhosis.<\/jats:p>","DOI":"10.1155\/2019\/5459427","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T19:31:57Z","timestamp":1554751917000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Splenectomy on the Reversal of Cirrhosis: a Prospective Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-5659","authenticated-orcid":true,"given":"Dao-Bing","family":"Zeng","sequence":"first","affiliation":[{"name":"General Surgery Department, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Di","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Liang","family":"Guo","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin-Wei","family":"Duan","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui-Yu","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Dong","family":"Lin","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-jin","family":"Zang","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing You\u2019an Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-0534","authenticated-orcid":true,"given":"Shi-Chun","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute & Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450117666160613101413"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24621"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201840109"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.20240"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.009"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02774.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22694"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23785"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2015.107"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24401"},{"issue":"1","key":"11","first-page":"33","volume":"12","year":"2016","journal-title":"Gastroenterology & hepatology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2018.0018"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2017.05.005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.052"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-4-22"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04055.x"},{"issue":"47","key":"17","first-page":"1369","volume":"49","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02172.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i17.2069"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000392"},{"issue":"11","key":"21","first-page":"15260","volume":"8","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"22","first-page":"19","volume":"13","year":"2014","journal-title":"Chinese Journal of Digestive Surgery"},{"key":"23","first-page":"648","volume":"20","year":"2014","journal-title":"Chinese Journal of Hepatobiliary Surgery"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12234"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1292"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.443"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(99)00161-5"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.4137\/BMI.S10009"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v7.i6.872"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1018"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27376"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230648"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91946-J"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2006.00730.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041964"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01466.x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i9.2092"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3298"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i2.297"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i3.607"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3683"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5794"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-018-0053-6"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gox012"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3732-7"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140374"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-014-9575-z"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s005350200005"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200502000-00008"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i24.3138"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1155\/1995\/67691"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2004.198"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(13)60115-7"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/5459427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/5459427.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2019\/5459427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T19:31:59Z","timestamp":1554751919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2019\/5459427\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":53,"alternative-id":["5459427","5459427"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5459427","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]}}}