{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:41:55Z","timestamp":1790836915137,"version":"4.1.0"},"reference-count":254,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2019,3,20]]},"abstract":"<jats:p>Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades. To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts\u2019 immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells. Its better toxicity profile, lower cost, and easier use are main advantages over conventional therapies. The evidence of metronomic chemotherapy for personalized medicine is growing, starting with unfit elderly patients and also for palliative treatment. The literature reviewed in this article mainly demonstrates that metronomic chemotherapy is advantageous for selected patients and for certain types of malignancies, which make it a promising therapeutic approach for filling in the gaps. More clinical studies are needed to establish a solidified role for metronomic chemotherapy with other treatment models in modern cancer management.<\/jats:p>","DOI":"10.1155\/2019\/5483791","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T19:31:35Z","timestamp":1553110295000},"page":"1-31","source":"Crossref","is-referenced-by-count":122,"title":["Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-5233","authenticated-orcid":true,"given":"Cem","family":"Simsek","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-9906","authenticated-orcid":true,"given":"Ece","family":"Esin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, A.Y. Ankara Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suayib","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"7","key":"50","first-page":"1878","volume":"60","year":"2000","journal-title":"Cancer Research"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9872"},{"key":"231","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-009-0108-y"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.64"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70056-1"},{"issue":"23","key":"41","first-page":"6938","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12251"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvs152"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950130106"},{"issue":"12","key":"242","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1182\/blood.V94.12.4143","volume":"94","year":"1999","journal-title":"Blood"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-012-9321-x"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/832649"},{"issue":"15","key":"34","first-page":"4342","volume":"63","year":"2003","journal-title":"Cancer Research"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2135406100"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-005-0163-8"},{"key":"139","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1073\/pnas.0812801106","volume":"106","year":"2009","journal-title":"Proceedings of the National Acadamy of Sciences of the United States of America"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj066"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0505-6"},{"key":"251","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1582-4934.2011.01437.x","volume":"16","year":"2012","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-009-0671-1"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-006-0225-8"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041170"},{"key":"247","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3690"},{"key":"233","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1106"},{"key":"213","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2009.11.011"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28070"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0950"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-010-0005-5"},{"key":"234","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.05.007"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.493"},{"key":"224","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0245-0"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.34"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1242-4"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1038\/35102167"},{"key":"222","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.215"},{"key":"248","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28259"},{"key":"256","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024397"},{"key":"196","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.093"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0267"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2256"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2186"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.06.002"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.04.011"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.82"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2014.05.011"},{"key":"238","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0201"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21203"},{"issue":"1","key":"68","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/annonc\/mdf013","volume":"13","year":"2002","journal-title":"Annals of Oncology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.563"},{"key":"136","volume":"25","year":"2014","journal-title":"Annals of Oncology"},{"key":"177","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000224454.46824.fc"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32834e735a"},{"issue":"2","key":"96","first-page":"529","volume":"32","year":"2012","journal-title":"Anticancer Reseach"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2017.10.005"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2017.05.001"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.01.027"},{"issue":"45","key":"262","doi-asserted-by":"crossref","first-page":"79527","DOI":"10.18632\/oncotarget.18539","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2008.20.5.632"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2256-5"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.2217\/fon.12.196"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2012.01278.x"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.02.014"},{"key":"225","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/710292"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2010.22.3.201"},{"key":"252","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1728-3"},{"key":"259","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1826-x"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00058-6"},{"key":"230","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-2068-7"},{"key":"253","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.3939"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013034311284"},{"key":"217","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1663-3"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/769790"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-4009-3"},{"issue":"2","key":"260","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.3747\/co.19.879","volume":"19","year":"2012","journal-title":"Current Oncology"},{"key":"218","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2013.09.003"},{"key":"178","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-013-0483-1"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6377"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2015.03.002"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2017.08.013"},{"key":"163","first-page":"284","volume":"3","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"246","first-page":"S47","volume":"36","year":"2017","journal-title":"Breast"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2014.11.003"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2010.n.039"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1945-4"},{"issue":"2","key":"214","first-page":"215","volume":"16","year":"2011","journal-title":"Journal of B.U.ON."},{"key":"75","doi-asserted-by":"publisher","DOI":"10.5301\/tj.5000207"},{"issue":"suppl. c","key":"54","first-page":"27","volume":"19","year":"1993","journal-title":"Cancer Treatment Reviews"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/BF00665790"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.5.986"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686513"},{"key":"166","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00001813-199607000-00009","volume":"7","year":"1996","journal-title":"Anticancer Drugs"},{"key":"261","doi-asserted-by":"crossref","first-page":"e774","DOI":"10.1097\/MD.0000000000000774","volume":"94","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"243","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2015.01.008"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1993.tb16222.x"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2004.08.006"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.143"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11713"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9218-8"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0444-3"},{"issue":"10","key":"137","first-page":"4317","volume":"30","year":"2010","journal-title":"Anticancer Reseach"},{"key":"258","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2014.02.007"},{"key":"52","volume":"34","year":"2016","journal-title":"Journal of Clinical Oncology"},{"key":"73","volume":"27","year":"2016","journal-title":"Annals of Oncology"},{"key":"88","volume":"27","year":"2016","journal-title":"Annals of Oncology"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11686"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25976"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02833.x"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3317"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.08.010"},{"key":"176","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.398"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12583"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.154"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.3.3664"},{"key":"156","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00432-011-1101-2","volume":"138","year":"2012","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1438::AID-CNCR23>3.0.CO;2-O"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1159\/000055296"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq178"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28953"},{"key":"119","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3892\/etm.2011.272","volume":"2","year":"2011","journal-title":"Experimental and Therapeutic Medicine"},{"key":"195","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20010301)46:4<257::AID-PROS1031>3.0.CO;2-4"},{"issue":"4","key":"244","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1464-410X.2007.07261.x","volume":"101","year":"2008","journal-title":"BJU International"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960315)77:6<1144::AID-CNCR21>3.0.CO;2-0"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.3892\/ol_00000013"},{"issue":"4","key":"208","first-page":"885","volume":"10","year":"2003","journal-title":"Oncology Reports"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-016-0385-0"},{"key":"237","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2015.12.003"},{"key":"250","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-015-9696-3"},{"key":"266","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2013.07.004"},{"issue":"8","key":"53","volume":"33","year":"2016","journal-title":"Medical Oncology"},{"issue":"3","key":"21","first-page":"587","volume":"5","year":"1999","journal-title":"Clinical Cancer Research"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3282"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104390"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330X.181627"},{"key":"79","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/2278-330X.181629","volume":"5","year":"2016","journal-title":"South Asian Journal of Cancer"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1007\/BF01209489"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.8.3973"},{"key":"215","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2407-7-54","volume":"7","year":"2007","journal-title":"BMC Cancer"},{"issue":"1","key":"89","volume":"14","year":"2014","journal-title":"BMC Cancer"},{"key":"36","volume":"33","year":"2015","journal-title":"Journal of Clinical Oncology"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.05.013"},{"key":"216","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000320602","volume":"79","year":"2010","journal-title":"Oncology"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.1939"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2013.24.3.258"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-008-0254-7"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.07.017"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25967"},{"key":"198","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.4489"},{"key":"211","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.03.008"},{"key":"265","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"200","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.08.033"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-214"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.08.002"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2006.0083"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23164"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.117032"},{"key":"235","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600827"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2007-006"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.7944"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop030"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.5520"},{"key":"255","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2015.58.5.426"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos295"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03778.x"},{"key":"239","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0620-5"},{"key":"227","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0192-y"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605412"},{"key":"202","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0403-6"},{"key":"245","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp591"},{"issue":"8","key":"267","first-page":"3487","volume":"33","year":"2013","journal-title":"Anticancer Reseach"},{"key":"118","volume":"7","year":"2015","journal-title":"Science Translational Medicine"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70383-3"},{"key":"249","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9982-0"},{"key":"240","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2014.0106"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.24.1892"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199810000-00018"},{"key":"228","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.02.016"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.03.024"},{"issue":"1","key":"71","first-page":"133","volume":"16","year":"2006","journal-title":"Oncology Reports"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1159\/000118626"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.12.2.15722"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1179\/1973947812Y.0000000050"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23859"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1159\/000192586"},{"issue":"44","key":"187","doi-asserted-by":"crossref","first-page":"75904","DOI":"10.18632\/oncotarget.20411","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-015-2707-x"},{"key":"232","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.04.001"},{"key":"226","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2006.18.2.188"},{"issue":"1","key":"55","volume":"15","year":"2015","journal-title":"BMC Cancer"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3747\/co.24.3486"},{"key":"28","first-page":"S907","volume":"12","year":"2017","journal-title":"Journal of Thoracic Oncology"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.02.004"},{"issue":"20","key":"205","volume":"3","year":"2015","journal-title":"Annals of Translational Medicine"},{"issue":"3","key":"87","first-page":"192","volume":"7","year":"2012","journal-title":"Bangladesh Journal of Pharmacology"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12019"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2015.05.005"},{"issue":"6","key":"56","first-page":"1290","volume":"21","year":"2009","journal-title":"Annals of Oncology"},{"key":"172","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/2278-330X.181643","volume":"5","year":"2016","journal-title":"South Asian Journal of Cancer"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-012-9260-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604311"},{"key":"69","first-page":"1169","volume":"3","year":"1996","journal-title":"Oncology Reports"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9791-x"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.117020"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000308"},{"key":"201","volume":"26","year":"2015","journal-title":"Annals of Oncology"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0377-4"},{"key":"209","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s12032-015-0496-z","volume":"32","year":"2015","journal-title":"Medical Oncology"},{"issue":"4","key":"173","first-page":"475","volume":"26","year":"2007","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"58","volume":"29","year":"2011","journal-title":"Journal of Clinical Oncology"},{"key":"210","volume":"32","year":"2015","journal-title":"Medical Oncology"},{"key":"44","volume":"27","year":"2016","journal-title":"Annals of Oncology"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv490"},{"issue":"3","key":"115","volume":"12","year":"2017","journal-title":"PLoS ONE"},{"key":"221","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62004-3"},{"key":"86","volume":"27","year":"2016","journal-title":"Annals of Oncology"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1177\/548.6527"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0093"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.03.010"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.01.035"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0465"},{"key":"219","doi-asserted-by":"publisher","DOI":"10.1159\/000336126"},{"key":"254","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2012.18.1.32"},{"key":"95","volume":"7","year":"2017","journal-title":"Scientific Reports"},{"key":"257","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.0071"},{"key":"197","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.5.3922"},{"key":"37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/lrb.2008.1016","volume":"6","year":"2008","journal-title":"Lymphatic Research and Biology"},{"key":"223","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412102"},{"key":"229","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-1-99"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13100"},{"key":"263","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.005"},{"key":"264","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.887711"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.085183"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-729236"},{"key":"62","volume":"128","year":"2016","journal-title":"Blood"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12418"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0083-7"},{"key":"241","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.577"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24902"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-009-9298-5"},{"key":"220","volume":"27","year":"2009","journal-title":"Journal of Clinical Oncology"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.166725"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.117024"},{"key":"183","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4103\/2278-330X.181625","volume":"5","year":"2016","journal-title":"South Asian Journal of Cancer"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330X.181624"},{"issue":"1","key":"189","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/ijc.IJC_161_17","volume":"54","year":"2017","journal-title":"Indian Journal of Cancer"},{"issue":"1","key":"33","volume":"14","year":"2014","journal-title":"BMC Cancer"},{"key":"212","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh384"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208939"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.11.025"},{"key":"24","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.2174\/156802612803531432","volume":"12","year":"2012","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"46","first-page":"463","volume":"8","year":"2014","journal-title":"Ecancermedicalscience"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.14.14"},{"key":"236","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.038"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2019\/5483791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2019\/5483791.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2019\/5483791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T19:37:24Z","timestamp":1721072244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2019\/5483791\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,20]]},"references-count":254,"alternative-id":["5483791","5483791"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5483791","relation":{},"ISSN":["1687-8450","1687-8469"],"issn-type":[{"value":"1687-8450","type":"print"},{"value":"1687-8469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,20]]}}}