{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:53:15Z","timestamp":1791575595629,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Montpellier University Hospital"},{"name":"French Ministry of Public Health"},{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"publisher"}]},{"name":"5 Sant\u00e9\/Fontalvie Corporation"},{"name":"Agir \u00e0 Dom\/Homair"},{"name":"Bastide Medical"},{"name":"SOS Oxygene"},{"DOI":"10.13039\/501100013873","name":"APARD","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013873","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,4,17]]},"abstract":"Background<\/jats:italic>. Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD) is not fully reversed by exercise training. Antioxidants are critical for muscle homeostasis and adaptation to training. However, COPD patients experience antioxidant deficits that worsen after training and might impact their muscle response to training. Nutritional antioxidant supplementation in combination with pulmonary rehabilitation (PR) would further improve muscle function, oxidative stress, and PR outcomes in COPD patients. Methods<\/jats:italic>. Sixty-four COPD patients admitted to inpatient PR were randomized to receive 28 days of oral antioxidant supplementation targeting the previously observed deficits (PR antioxidant group; \u03b1<\/jats:italic>-tocopherol: 30\u2009mg\/day, ascorbate: 180\u2009mg\/day, zinc gluconate: 15\u2009mg\/day, selenomethionine: 50\u2009\u03bc<\/jats:italic>g\/day) or placebo (PR placebo group). PR consisted of 24 sessions of moderate-intensity exercise training. Changes in muscle endurance (primary outcome), oxidative stress, and PR outcomes were assessed. Results<\/jats:italic>. Eighty-one percent of the patients (FE<\/mml:mtext>V<\/mml:mtext><\/mml:mrow>1<\/mml:mn><\/mml:mrow><\/mml:msub>=<\/mml:mo>58.9<\/mml:mn>\u00b1<\/mml:mo>20.0<\/mml:mn><\/mml:math>%pred) showed at least one nutritional antioxidant deficit. Training improved muscle endurance in the PR placebo group (+37.4<\/mml:mn>\u00b1<\/mml:mo>45.1<\/mml:mn><\/mml:math>%, p<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>), without additional increase in the PR antioxidant group (-6.6<\/mml:mn>\u00b1<\/mml:mo>11.3<\/mml:mn><\/mml:math>%; p<\/mml:mi>=<\/mml:mo>0.56<\/mml:mn><\/mml:math>). Nevertheless, supplementation increased the \u03b1<\/jats:italic>-tocopherol\/\u03b3<\/jats:italic>-tocopherol ratio and selenium (+58<\/mml:mn>\u00b1<\/mml:mo>20<\/mml:mn><\/mml:math>%, p<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>, and +16<\/mml:mn>\u00b1<\/mml:mo>5<\/mml:mn><\/mml:math>%, p<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>, respectively), muscle strength (+11<\/mml:mn>\u00b1<\/mml:mo>3<\/mml:mn><\/mml:math>%, p<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>), and serum total proteins (+7<\/mml:mn>\u00b1<\/mml:mo>2<\/mml:mn><\/mml:math>%, p<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>), and it tended to increase the type I fiber proportion (+32<\/mml:mn>\u00b1<\/mml:mo>17<\/mml:mn><\/mml:math>%, p<\/mml:mi>=<\/mml:mo>0.07<\/mml:mn><\/mml:math>). The prevalence of muscle weakness decreased in the PR antioxidant group only, from 30.0 to 10.7% (p<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). Conclusions<\/jats:italic>. While the primary outcome was not significantly improved, COPD patients demonstrate significant improvements of secondary outcomes (muscle strength and other training-refractory outcomes), suggesting a potential \u201cadd-on\u201d effect of the nutritional antioxidant supplementation (vitamins C and E, zinc, and selenium) during PR. This trial is registered with NCT01942889<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2019\/5496346","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:08:28Z","timestamp":1555546108000},"page":"1-13","source":"Crossref","is-referenced-by-count":35,"title":["Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-866X","authenticated-orcid":true,"given":"Fares","family":"Gouzi","sequence":"first","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Maury","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, France"},{"name":"Pulmonary Rehabilitation Centers Les Cliniques du Souffle\u00ae, 5 Sant\u00e9\/Fontalvie Corporation, 66350 Toulouges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"H\u00e9raud","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation Centers Les Cliniques du Souffle\u00ae, 5 Sant\u00e9\/Fontalvie Corporation, 66350 Toulouges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Molinari","sequence":"additional","affiliation":[{"name":"IMAG, CNRS, Montpellier University, Montpellier University Hospital, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e9na","family":"Bertet","sequence":"additional","affiliation":[{"name":"IMAG, CNRS, Montpellier University, Montpellier University Hospital, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronia","family":"Ayoub","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Blaqui\u00e8re","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bughin","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"De Rigal","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation Centers Les Cliniques du Souffle\u00ae, 5 Sant\u00e9\/Fontalvie Corporation, 66350 Toulouges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Poulain","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation Centers Les Cliniques du Souffle\u00ae, 5 Sant\u00e9\/Fontalvie Corporation, 66350 Toulouges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Pincemail","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery and CREDEC, University of Li\u00e8ge, Sart Tilman University Hospital, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-7278","authenticated-orcid":true,"given":"Jean-Paul","family":"Cristol","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Laoudj-Chenivesse","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Mercier","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pr\u00e9faut","sequence":"additional","affiliation":[{"name":"Montpellier University, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-6087","authenticated-orcid":true,"given":"Pascal","family":"Pomi\u00e8s","sequence":"additional","affiliation":[{"name":"PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, 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