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Although many adjunctive strategies have been applied for the treatment of DFUs, the low treatment efficiency, potential side effects, and high cost are still huge challenges. Recently, nanomaterial-based drug delivery systems (NDDSs) have achieved targeted drug delivery and controlled drug release, offering great promises in various therapeutics for diverse disorders. Additionally, the radial extracorporeal shock wave (rESW) has been shown to function as a robust trigger source for the NDDS to release its contents, as the rESW harbors a potent capability in generating pressure waves and in creating the cavitation effect. Here, we explored the performance of oxygen-loaded nanoperfluorocarbon (Nano-PFC) combined with the rESW as a treatment for DFUs. Prior to<jats:italic>in vivo<\/jats:italic>assessment, we first demonstrated the high oxygen affinity<jats:italic>in vitro<\/jats:italic>and great biocompatibility of Nano-PFC. Moreover, the rESW-responsive oxygen release behavior from oxygen-saturated Nano-PFC was also successfully verified<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>. Importantly, the wound healing of DFUs was significantly accelerated due to improved blood microcirculation, which was a result of rESW therapy (rESWT), and the targeted release of oxygen into the wound from oxygen-loaded Nano-PFC, which was triggered by the rESW. Collectively, the oxygen-saturated Nano-PFC and rESW provide a completely new approach to treat DFUs, and this study highlights the advantages of combining nanotechnology with rESW in therapeutics.<\/jats:p>","DOI":"10.1155\/2019\/5738368","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T23:32:19Z","timestamp":1565825539000},"page":"1-10","source":"Crossref","is-referenced-by-count":22,"title":["Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave"],"prefix":"10.1155","volume":"2019","author":[{"given":"Shunhao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, 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