{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:38:35Z","timestamp":1761676715450,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish National Centre of Science","award":["2016\/23\/N\/NZ5\/02573"],"award-info":[{"award-number":["2016\/23\/N\/NZ5\/02573"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2019,2,27]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Hepcidin is an acute-phase protein involved also in regulation of iron homeostasis. The aim of the study was to prospectively assess for the first time the hepcidin<jats:sub>EL<\/jats:sub> concentration in patients with subacute thyroiditis (SAT), to identify biochemical determinants of hepcidin<jats:sub>EL<\/jats:sub> concentration and evaluate the potential role of hepcidin in SAT diagnosis and monitoring. <jats:italic>Methods<\/jats:italic>. Out of 40 patients with SAT initially recruited, restrictive inclusion criteria fulfilled 21 subjects aged <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>45<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math> years and 21 healthy control subjects (CS). Hepcidin<jats:sub>EL<\/jats:sub> concentration, thyroid status, and iron homeostasis were evaluated at SAT diagnosis and following therapy and compared with CS. <jats:italic>Results<\/jats:italic>. The median hepcidin<jats:sub>EL<\/jats:sub> concentration at SAT diagnosis is higher than that in CS (48.8 (15.9-74.5) ng\/mL vs. 18.2 (10.2-23.3) ng\/mL, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>) and is significantly lower after treatment (4.0 (1.2-10.0) ng\/mL, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>) compared with CS. The ROC analysis for hepcidin<jats:sub>EL<\/jats:sub> at SAT diagnosis revealed that area under the curve (AUC) is 0.735 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>), and the cut-off for hepcidin<jats:sub>EL<\/jats:sub> concentration is 48.8\u2009ng\/mL (sensitivity 0.52 and specificity 0.95). Hepcidin<jats:sub>EL<\/jats:sub> in SAT patients correlated with CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.614<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>), ferritin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.815<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and aTPO (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>r<\/mml:mi><\/mml:math>\u2009=\u2009-0.491, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.024<\/mml:mn><\/mml:math>). On multiple regression, the correlation between hepcidin<jats:sub>EL<\/jats:sub> and ferritin was confirmed (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. SAT is accompanied by a significant increase in hepcidin, which reflects an acute-phase inflammatory process. Parameters of iron homeostasis improved significantly while inflammatory indices got lower following recovery. The potential role of hepcidin as a predictive factor of the risk of SAT relapse needs to be assessed in studies on larger groups of SAT patients.<\/jats:p>","DOI":"10.1155\/2019\/5764061","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T19:07:04Z","timestamp":1551294424000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects"],"prefix":"10.1155","volume":"2019","author":[{"given":"Aleksandra","family":"Hernik","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-3274","authenticated-orcid":true,"given":"Ewelina","family":"Szczepanek-Parulska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal 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