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Characterization of the surface modified GE was carried out by cyclic voltammetry and electrochemical impedance spectroscopy using ferrocene as a redox probe. Under the optimized experimental conditions, a detection limit of 0.5 ng\/mL (3<jats:italic>\u03c3<\/jats:italic>\/slope) was obtained by the present electrochemical biosensor, along with a linear range of 0-110 ng\/mL. 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