{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:14:46Z","timestamp":1780398886975,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,12,23]]},"abstract":"<jats:p>Amiselimod (MT-1303) is a novel and selective sphingosine 1-phosphate receptor-1 (S1P<jats:sub>1<\/jats:sub>) modulator with a more favorable cardiac safety profile than other S1P<jats:sub>1<\/jats:sub> receptor modulators. In this study, we evaluated the effects of MT-1303 on the progression of lupus nephritis in two well-known murine systemic lupus erythematosus (SLE) models, MRL\/<jats:italic>lpr<\/jats:italic> and NZBWF1 mice, compared with those of FK506. Daily oral doses of 0.1 and 0.3\u2009mg\/kg MT-1303 not only inhibited the development of lupus nephritis when administered before onset in MRL\/<jats:italic>lpr<\/jats:italic> and NZBWF1 mice but also improved symptoms of lupus nephritis when administered after onset in MRL\/<jats:italic>lpr<\/jats:italic> mice. Its efficacy in these models was more potent or comparable to that of FK506 (1 and 3\u2009mg\/kg). In histological analysis, treatment with MT-1303 inhibited infiltration of T cells into the kidneys, mesangial expansion, and glomerular sclerosis. MT-1303 treatment resulted in a marked reduction in T cells and B cells in the peripheral blood and significantly inhibited increases in the number of plasma cells in the spleen and T cells in the kidneys. In addition, administration of MT-1303 suppressed elevations in serum anti-dsDNA antibody levels in MRL\/<jats:italic>lpr<\/jats:italic> mice, but not in NZBWF1 mice. Our findings show that MT-1303 exhibits marked therapeutic effects on lupus nephritis in two SLE models, likely by reducing the infiltration of autoreactive T cells into the kidneys. These results suggest that MT-1303 has the potential to be used as a therapeutic agent for patients suffering from SLE, including lupus nephritis.<\/jats:p>","DOI":"10.1155\/2019\/5821589","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T18:30:59Z","timestamp":1577125859000},"page":"1-11","source":"Crossref","is-referenced-by-count":19,"title":["Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5782-4540","authenticated-orcid":true,"given":"Kunio","family":"Sugahara","sequence":"first","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-5364","authenticated-orcid":true,"given":"Kyoko","family":"Shimano","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikako","family":"Murase","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Mochiduki","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiro","family":"Kakimoto","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Utsumi","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-1534","authenticated-orcid":true,"given":"Koichi","family":"Oshita","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13641"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13203"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30192-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.817"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/827254"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/ar3251"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/bf00541370"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205171"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205139"},{"issue":"9","key":"11","first-page":"1955","volume":"30","year":"2003","journal-title":"The Journal of Rheumatology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.158"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01088"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.10.005"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907839"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513248"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2075"},{"issue":"4","key":"19","first-page":"707","volume":"29","year":"2002","journal-title":"The Journal of Rheumatology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306073136"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.396"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193236"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.078"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1198"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-2776(08)60444-7"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211499"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/759313"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802626"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8761"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226154"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001302"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy222.082"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31773-8"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122636"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/5821589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/5821589.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2019\/5821589.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T18:31:00Z","timestamp":1577125860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2019\/5821589\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":35,"alternative-id":["5821589","5821589"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5821589","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]}}}