{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:56:48Z","timestamp":1787950608650,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,7,14]]},"abstract":"<jats:p>In prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling. We evaluated the HP<jats:italic>\u03b2<\/jats:italic>CD\/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS. After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated with cyclodextrin (HP<jats:italic>\u03b2<\/jats:italic>CD) or HP<jats:italic>\u03b2<\/jats:italic>CD\/Ang-(1-7) in the last 6 weeks. FAT-HP<jats:italic>\u03b2<\/jats:italic>CD\/empty rats showed increased adiposity index and body mass, gene expression of ACE\/ANG II\/AT1R axis, and oxidative stress. These results were accompanied by imbalances in the insulin pathway, worsening of liver function, hyperglycemia, and dyslipidemia. Oral HP<jats:italic>\u03b2<\/jats:italic>CD\/Ang-(1-7) treatment decreased <jats:italic>ACE<\/jats:italic> and <jats:italic>AT1R<\/jats:italic>, increased <jats:italic>ACE2<\/jats:italic> gene expression in the liver, and restored thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), insulin receptor substrate (<jats:italic>Irs-1<\/jats:italic>), glucose transporter type 4 (<jats:italic>GLUT4<\/jats:italic>), and serine\/threonine kinase 2 (<jats:italic>AKT-2<\/jats:italic>) gene expression in the liver and gastrocnemius muscle improving hepatic function, cholesterol levels, and hyperglycemia in MetS rats. Overall, HP<jats:italic>\u03b2<\/jats:italic>CD\/Ang-(1-7) treatment restored the RAS components, oxidative stress, and insulin signaling in the liver and gastrocnemius muscle contributing to the establishment of blood glucose and lipid homeostasis in MetS rats.<\/jats:p>","DOI":"10.1155\/2019\/5868935","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T19:31:34Z","timestamp":1563132694000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-8864","authenticated-orcid":true,"given":"Vivian Paulino","family":"Figueiredo","sequence":"first","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Andrea","family":"Barbosa","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uberdan Guilherme Mendes","family":"de Castro","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Cruz","family":"Zacarias","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-5196","authenticated-orcid":true,"given":"Frank Silva","family":"Bezerra","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Guerra","family":"de S\u00e1","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderson Geraldo","family":"de Lima","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5852","authenticated-orcid":true,"given":"Robson Augusto Souza","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5543-2140","authenticated-orcid":true,"given":"Andr\u00e9ia Carvalho","family":"Alzamora","sequence":"additional","affiliation":[{"name":"NUPEP, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil"},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01274"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/35055575"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.02.018"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.03.006"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/181643"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2017.1315513"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.10.005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0348-z"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21625"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90678.2008"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-136"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.05.024"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.08.011"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000500021"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-018-0637-x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.33"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1087-0"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00919"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0953"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i25.8082"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.013"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.10.022"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2012.04.001"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0792"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601320200"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1553"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1021\/pr3001755"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704357200"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06935"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/5868935.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/5868935.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/5868935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T12:41:30Z","timestamp":1569242490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2019\/5868935\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,14]]},"references-count":30,"alternative-id":["5868935","5868935"],"URL":"https:\/\/doi.org\/10.1155\/2019\/5868935","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,14]]}}}