{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:30:14Z","timestamp":1740169814909,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"],"award-info":[{"award-number":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010848","name":"Health and Family Planning Commission of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"],"award-info":[{"award-number":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"]}],"id":[{"id":"10.13039\/501100010848","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jining Science and Technology Bureau","award":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"],"award-info":[{"award-number":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"]}]},{"name":"PhD Research Foundation of the Affiliated Hospital of Jining Medical University","award":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"],"award-info":[{"award-number":["ZR2014HP058","2014-032","2017SMNS007","2017-BS-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,4,3]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> This study aimed to examine the relationship between serum alanine aminotransferase (ALT) and growth hormone (GH) in children and adolescents with short stature.<jats:italic> Methods.<\/jats:italic> In this retrospective cohort study, 670 Chinese children and adolescents with short stature were included, and 253 of them received recombinant human GH (rhGH) therapy. Anthropometric and biochemical indicators were measured. GH peak levels were assessed after provocation tests with L-dopa and insulin. The subjects were divided into 3 groups according to the GH peak level. The association between the GH peak and ALT was analyzed. The change of ALT during rhGH therapy was assessed by a generalized additive mixed model.<jats:italic> Results<\/jats:italic>. Serum ALT and incidence of ALT elevation were both decreased across the GH tertiles (<jats:italic>P = <\/jats:italic>0.002, 0.012, respectively). A univariate analysis showed that the GH peak was negatively associated with ALT (<jats:italic>\u03b2<\/jats:italic>: -0.12; 95%CI: -0.22, -0.02;<jats:italic> P <\/jats:italic>= 0.023). Furthermore, multiple linear stepwise regression analysis demonstrated that the GH peak was independently related to ALT after adjusting for other confounding variables (<jats:italic>\u03b2<\/jats:italic>: -0.12; 95%CI: -0.24, -0.00;<jats:italic> P<\/jats:italic> = 0.042). Besides, mean values of the change in ALT from baseline displayed that, during the early stages of rhGH treatment, serum ALT level indicated a temporary upward trend, but it subsequently gradually decreased (<jats:italic>\u03b2<\/jats:italic>: -0.16; 95%CI: -0.23, -0.09;<jats:italic> P<\/jats:italic> &lt; 0.001).<jats:italic> Conclusions. <\/jats:italic>GH secretion level was strongly negatively correlated with ALT in short children and adolescents. And rhGH therapy could reduce ALT level over time.<\/jats:p>","DOI":"10.1155\/2019\/5939372","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:34:25Z","timestamp":1554320065000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Association between Alanine Aminotransferase and Growth Hormone: A Retrospective Cohort Study of Short Children and Adolescents"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-5995","authenticated-orcid":true,"given":"Baolan","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, China"},{"name":"Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong 272029, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntian","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Health Management and Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-0498","authenticated-orcid":true,"given":"Yanying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, China"},{"name":"Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong 272029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[{"name":"Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong 272029, China"},{"name":"Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-1422","authenticated-orcid":true,"given":"Bo","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, China"},{"name":"Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong 272029, 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