{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:59Z","timestamp":1792686059014,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2019,1,3]]},"abstract":"<jats:p><jats:italic>Purpose. <\/jats:italic>To study predictors of attaining (part 1) and sustaining (part 2) remission in patients with Graves\u2019 hyperthyroidism (GH) treated with antithyroid drugs (ATD).<jats:italic> Methods. <\/jats:italic>In the prospective first part, the included patients were treated with ATD until a prespecified definition of remission (thyrotropin &gt; 0.4 mU\/L and TSH-receptor antibodies (TRAb) \u2264 1. 0 IU\/L in a patient receiving a methimazole dose \u2264 5 mg\/day, on two occasions two months apart) was met, or for 24 months. In the second part, patients attaining remission in part 1 were randomized to treatment or observation and followed until relapse or for 24 months.<jats:italic> Results. <\/jats:italic>173 patients completed study 1 and 53% attained remission. TRAb and age were the only significant predictors of remission. Patients with baseline TRAb below vs above 10 IU\/L attained remission in 63% compared to 39%, and 5 months priorly (p&lt;0.001). In study 2, 96.4% of the patients randomized to treatment (n=33) sustained remission compared to 66% in the observation group (n=33). Treatment arm was the only significant parameter (p&lt;0.001) of sustained remission.<jats:italic> Conclusion. <\/jats:italic>Baseline TRAb was prognostic for attaining remission in GH. Consecutive TRAb measurements during treatment were not worthwhile, but a single measurement after 6-8 months in patients with initial TRAb &lt; 10 IU\/L could substantially shorten the treatment period in a subgroup of patients. Only 3.6% of the patients in remission experienced relapse during follow-up when treated with a combination of fixed low dose methimazole and L-T4.<jats:bold> ClinTrial.gov registration number is<\/jats:bold>\u2009\u2009<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00796913\">NCT00796913<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2019\/5945178","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T18:31:10Z","timestamp":1546540270000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Predictors of Initial and Sustained Remission in Patients Treated with Antithyroid Drugs for Graves\u2019 Hyperthyroidism: The RISG Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-5834","authenticated-orcid":true,"given":"J.","family":"Karmisholt","sequence":"first","affiliation":[{"name":"Dept. of Endocrinology, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Dept. of Clinical Institute, Aalborg University, 9100 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6336-1936","authenticated-orcid":true,"given":"S. L.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Dept. of Clinical Biochemistry, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bulow-Pedersen","sequence":"additional","affiliation":[{"name":"Dept. of Endocrinology, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Dept. of Clinical Institute, Aalborg University, 9100 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carl\u00e9","sequence":"additional","affiliation":[{"name":"Dept. of Endocrinology, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-5599","authenticated-orcid":true,"given":"A.","family":"Krejbjerg","sequence":"additional","affiliation":[{"name":"Dept. of Oncology, Aalborg University Hospital, 9000 Aalborg, 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