{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:25:12Z","timestamp":1792293912995,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Higher Education, C\u00f4te d\u2019Ivoire","award":["1540\/MESRS\/DB\/SD-BHCI\/SD\/CBK"],"award-info":[{"award-number":["1540\/MESRS\/DB\/SD-BHCI\/SD\/CBK"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,10,16]]},"abstract":"<jats:p>Native to Mexico,<jats:italic>Persea americana<\/jats:italic>Mill. (avocado) is a fruit tree whose different parts (leaf, bark, roots, and stone) are used in traditional medicine especially against diabetes mellitus. The aim of this study was to investigate the beneficial effects of 28-day treatment with aqueous, ethanolic, and methanolic leaf extracts on glucose homeostasis in type 2 diabetic mellitus using Wistar rats. Type 2 diabetes was induced with nicotinamide (120\u2009mg\/kg, i.p.) and streptozotocin (65\u2009mg\/kg, i.p.). After 28 days of treatment, histopathological examination of the pancreas, kidneys, liver, and muscle (tibialis anterior) were realized. Biochemical markers were determined and an intestinal absorption test of D-glucose was performed. All extracts (100\u2009mg\/kg\/day, p.o.) significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) reduced blood glucose level at the 28<jats:sup>th<\/jats:sup>day of treatment with a more pronounced effect for methanolic extract. The treatments were well tolerated and induced a restoration of T-CHOL and HDL-C levels compared to the control group. Methanolic extract reduced the AIP (atherogenic index of plasma) by 45%. Histopathological analyzes of the pancreas showed regeneration of islets of Langerhans. Methanolic extract was the most effective in preventing intestinal glucose uptake up to 60.90% in relation to metformin. These results justify the use of this plant in traditional medicine against type 2 diabetes. However, other complementary studies should be done to identify the molecules responsible for this activity and their signaling voice.<\/jats:p>","DOI":"10.1155\/2019\/5984570","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T23:30:43Z","timestamp":1571268643000},"page":"1-14","source":"Crossref","is-referenced-by-count":22,"title":["Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of<i>Persea americana<\/i>and Their Effectiveness in Type 2 Diabetic Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-0300","authenticated-orcid":true,"given":"N\u2019Goran M.","family":"Kouam\u00e9","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, UFR-SMB, Alassane Ouattara University, Bouak\u00e9, 01 BP V 18, Bouak\u00e9 01, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Koffi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, UFR-SMA, F\u00e9lix Houphou\u00ebt-Boigny University, Abidjan, 01 BP V 34, Abidjan 01, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanga S.","family":"N\u2019Zou\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, UFR-SMB, Alassane Ouattara University, Bouak\u00e9, 01 BP V 18, Bouak\u00e9 01, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u2019Guessan A. 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