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To investigate the effect of Nrf2 activator sulforaphane (SFN) on bladder compliance and the underlying mechanisms in a rat model of partial bladder outlet obstruction (BOO). <jats:italic>Methods<\/jats:italic>. Male 8-week-old Sprague-Dawley rats were divided into three groups. BOO rats were given daily 0.5\u2009mg\/kg sulforaphane (BOO+SFN) or vehicle (BOO) intraperitoneally for 4 weeks, while sham-operated rats were treated with vehicle (Sham). Bladder compliance, histological alteration, and collagen deposition were evaluated. The expression levels of collagen I, collagen III, MMP-1, and TIMP-1 were measured by immunohistochemistry and western blotting. <jats:italic>Results<\/jats:italic>. BOO led to a significant decrease in bladder compliance. The change was partially restored by SFN treatment. The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment. Moreover, the increased collagen I\/collagen III ratio in the BOO group was reversed by SFN treatment. <jats:italic>Conclusions<\/jats:italic>. Sulforaphane suppressed collagen deposition by regulating the MMP-1 and TIMP-1 expression and decreasing the collagen I\/III expression ratio in BOO rats and improved bladder compliance.<\/jats:p>","DOI":"10.1155\/2019\/6026719","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T19:35:50Z","timestamp":1560886550000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-422X","authenticated-orcid":true,"given":"Chong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of 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