{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:18:49Z","timestamp":1790291929907,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health System Research Institute","award":["HSRI 61-002"],"award-info":[{"award-number":["HSRI 61-002"]}]},{"name":"Health System Research Institute","award":["NRCT-2782"],"award-info":[{"award-number":["NRCT-2782"]}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["HSRI 61-002"],"award-info":[{"award-number":["HSRI 61-002"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["NRCT-2782"],"award-info":[{"award-number":["NRCT-2782"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,4,4]]},"abstract":"<jats:p>Cerebral involvement especially brain abscess is life-threatening complication and major cause of death during<jats:italic> Scedosporium apiospermum<\/jats:italic> infection. However, little is known about pathogenesis of brain oedema associated with abscess in scedosporiosis. Experimental scedosporiosis was conducted in BALB\/cMlac mice to characterize the presence of brain oedema, its type, and its related mechanisms focusing on aquaporin (AQP)-4, nuclear factor erythroid-2 related factor (Nrf-2), and tumor necrotic factor (TNF)-<jats:italic>\u03b1<\/jats:italic>. The results revealed that<jats:italic> S. apiospermum<\/jats:italic> infection induced severe inflammatory environment relevant to TNF-<jats:italic>\u03b1<\/jats:italic> expression and cytogenic oedema-associated brain abscess predominately in cerebrum of immunocompromised mice without voriconazole treatment reflecting to downregulation of AQP-4 in neighboring abscess areas and oedematous blood vessels. Downregulation of Nrf-2 in neuronal cells and myelin degeneration were significantly observed in nontreated mice. In summary, oxidative stress, severe inflammatory response, and space-occupying mass from abscess formation inducing tissue hypoxia might be the postulate causes of oedema induced by scedosporiosis.<\/jats:p>","DOI":"10.1155\/2019\/6076571","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T19:47:40Z","timestamp":1554407260000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-2996","authenticated-orcid":true,"given":"Sumate","family":"Ampawong","sequence":"first","affiliation":[{"name":"Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, 420\/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-5298","authenticated-orcid":true,"given":"Natthanej","family":"Luplertlop","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420\/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780600752507"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01489.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00039-07"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"e0123189","DOI":"10.1371\/journal.pone.0123189","volume":"10","year":"2015","journal-title":"PLoS ONE"},{"issue":"6","key":"5","first-page":"566","volume":"4","year":"2011","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2018.05.006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00065.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03362.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.5.0897"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/714031108"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.5.944"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00046-10"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.07.001"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200006000-00005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200202000-00017"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.2.262"},{"issue":"20","key":"17","doi-asserted-by":"crossref","first-page":"13131","DOI":"10.1073\/pnas.192457099","volume":"99","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"18","first-page":"3","volume":"60","year":"1994","journal-title":"Acta neurochirurgica. 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