{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:32Z","timestamp":1790790812003,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T00:00:00Z","timestamp":1549152000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological Sciences"],"published-print":{"date-parts":[[2019,2,3]]},"abstract":"<jats:p>Bergapten (5-methoxypsoralen, 5-MOP) is a plant-derived furocoumarin with demonstrated anti-inflammatory action. The present study investigated its effects on allergic inflammation in two related pathways of mast cell degranulation. Compound 48\/80 and lipopolysaccharide (LPS) were used to activate the IgE-independent pathway while bovine serum albumin (BSA) was used as allergen for the IgE-dependent pathway. The modulatory effect of bergapten on mast cell degranulation, neutrophil extravasation, protein concentration, lung histopathology, and oxidative stress was assessed. Bergapten at 10, 30, and 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml for 15\u2009min stabilized mast cells in rat mesenteric tissue from disruption<jats:italic>in vitro<\/jats:italic>and when administered<jats:italic>in vivo<\/jats:italic>at 3, 10, and 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>for 1\u2009h protected mice from fatal anaphylaxis induced by compound 48\/80. Similarly, treatment of LPS-challenged mice with bergapten (3, 10, and 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) for 24\u2009h significantly decreased neutrophil infiltration into bronchoalveolar lavage fluid, mean protein concentration, and inflammatory cell infiltration of pulmonary tissues when compared to the saline-treated LPS-challenged control. In addition, lung histology of the bergapten-treated LPS-challenged mice showed significantly less oedema, congestion, and alveolar septa thickening when compared to the saline-treated LPS-challenged disease control. LPS-induced oxidative stress was significantly reduced through increased tissue activities of catalase and superoxide dismutase and reduced malondialdehyde levels on treatment with bergapten. In the triple antigen-induced active anaphylaxis, daily administration of bergapten at 3, 10, and 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>for 10\u2009days, respectively, protected previously sensitized and challenged mice against anaphylactic shock. Overall, our study demonstrates the ability of bergapten to attenuate allergic airway-induced hypersensitivity in murine models of inflammation, suggesting its possible therapeutic benefit in this condition.<\/jats:p>","DOI":"10.1155\/2019\/6097349","type":"journal-article","created":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T23:33:32Z","timestamp":1549236812000},"page":"1-12","source":"Crossref","is-referenced-by-count":11,"title":["Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation"],"prefix":"10.1155","volume":"2019","author":[{"given":"Douglas B.","family":"Aidoo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology, KNUST, Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-9534","authenticated-orcid":true,"given":"David 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